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Diagnostic Performance of Resting and Hyperemic Invasive Physiological Indices to Define Myocardial Ischemia Validation With N-13-Ammonia Positron Emission Tomography 期刊论文

编号：

003160ea-0ae4-444d-a5d2-4a0e0baef71b
作者：

Hwang, Doyeon#^[1,2]Jeon, KiHyun^[3];Lee, Joo Myung^[4];Park, Jonghanne^[1,2];Kim, Chee Hae^[1,2];Tong, Yaliang(童亚良)^[5]Zhang, Jinlong^[1,2];Bang, JiIn^[6];Suh, Minseok^[6];Paeng, Jin Chul^[6];Na, SangHoon^[1,7,8];Cheon, Gi Jeong^[6];Cook, Christopher M.^[9,10];Davies, Justin E.^[9,10];Koo, BonKwon*^[1,2,8]
语种：

英文
期刊：

JACC-CARDIOVASCULAR INTERVENTIONS ISSN：1936-8798 2017 年 10 卷 8 期 (751 - 760) ; APR 24
收录：
关键词：

N-13-ammonia positron emission tomography coronary artery disease fractional flow reserve instantaneous wave-free ratio myocardial ischemia
摘要：

OBJECTIVES The authors sought to compare the diagnostic performance of fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and resting distal coronary artery pressure/aortic pressure (Pd/Pa) using 13N-ammonia positron emission tomography (PET).
BACKGROUND The diagnostic performance of invasive physiological indices was reported to be different according to the reference to define the presence of myocardial ischemia.
METHODS A total of 115 consecutive patients with left anterior descending artery stenosis who underwent both 13N-ammonia PET and invasive physiological measurement were included. Optimal cutoff values and diagnostic performance of FFR, iFR, and resting Pd/Pa were assessed using PET-derived coronary flow reserve (CFR) and relative flow reserve (RFR) as references. To compare discrimination and reclassification ability, each index was compared with integrated discrimination improvement (IDI) and category-free net reclassification index (NRI).
RESULTS All invasive physiological indices correlated with CFR and RFR (all p values <0.001). The overall diagnostic accuracies of FFR, iFR, and resting Pd/Pa were not different for CFR <2.0 (FFR 69.6%, iFR 73.9%, and resting Pd/Pa 70.4%) and RFR <0.75 (FFR 73.9%, iFR 71.3%, and resting Pd/Pa 74.8%). Discrimination and reclassification abilities of invasive physiological indices were comparable for CFR. For RFR, FFR showed better discrimination and reclassification ability than resting indices (IDI = 0.170 and category-free NRI = 0.971 for iFR; IDI = 0.183 and category-free NRI = 1.058 for resting Pd/Pa; all p values <0.001).
CONCLUSIONS The diagnostic performance of invasive physiological indices showed no differences in the prediction of myocardial ischemia defined by CFR. Using RFR as a reference, FFR showed a better discrimination and reclassification ability than resting indices. (C) 2017 by the American College of Cardiology Foundation.
推荐引用方式
GB/T 7714：

Hwang Doyeon,Jeon Ki-Hyun,Lee Joo Myung, et al. Diagnostic Performance of Resting and Hyperemic Invasive Physiological Indices to Define Myocardial Ischemia Validation With N-13-Ammonia Positron Emission Tomography [J].JACC-CARDIOVASCULAR INTERVENTIONS,2017,10(8):751-760.
APA：

Hwang Doyeon,Jeon Ki-Hyun,Lee Joo Myung,Park Jonghanne,&Koo Bon-Kwon.(2017).Diagnostic Performance of Resting and Hyperemic Invasive Physiological Indices to Define Myocardial Ischemia Validation With N-13-Ammonia Positron Emission Tomography .JACC-CARDIOVASCULAR INTERVENTIONS,10(8):751-760.
MLA：

Hwang Doyeon, et al. "Diagnostic Performance of Resting and Hyperemic Invasive Physiological Indices to Define Myocardial Ischemia Validation With N-13-Ammonia Positron Emission Tomography" .JACC-CARDIOVASCULAR INTERVENTIONS 10,8(2017):751-760.
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