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Tatarinan O, a lignin-like compound from the roots of Acorus tatarinowii Schott inhibits osteoclast differentiation through suppressing the expression of c-Fos and NFATc1 期刊论文

编号：

00e183e6-7f54-460f-b589-f3cc5e15611d
作者：

Xu, Xiaohan#^[1,2]Liu, Ning^[3];Wang, Yingjian(王瑛坚)^[4]Pan, Leichang^[1];Wu, Donglin^[5];Peng, Qisheng^[1];Zhang, Maolin^[1];Wang, Hongbing(王红兵)*^[2]Sun, Wanchun*^[1]
语种：

英文
期刊：

INTERNATIONAL IMMUNOPHARMACOLOGY ISSN：1567-5769 2016 年 34 卷 (212 - 219) ; MAY
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关键词：

Tatarinan O Osteoclast Bone resorption NFATc1 c-Fos RANKL
摘要：

Osteoclasts (OC) are large multinucleated cells derived from monocyte/macrophage precursors. Suppressing osteoclastogenesis is considered as an effective therapeutic approach to erosive bone disease. The root of Acorus tatarinowii Schott, a well-known traditional Chinese medicine was used to treat rheumatosis and other inflammatory disease. However, the effects of tatarinan O (TO), one of the lignin-like compounds isolated from the roots of Acorus tatarinowii Schott during bone development are still unclear. In the present study, we explored the effect of TO on RANKL-induced osteoclastogenesis in vitro. TO was found to suppress osteoclast differentiation from RANKL-stimulated mouse bone marrow macrophages (BMMs) without significant cytotoxicity. TO also dose dependently suppressed bone resorption activity of mature osteoclasts. Additionally, TO apparently inhibited the expression of osteoclastic marker genes, such as MMP-9, Cts K and TRAP. Furthermore, our results showed that TO decreased RANKL-induced expression of c-Fos and NFATc1 without influencing NF-kappa B activation and MAPK phosphorylation. Hence, for the first time we revealed that TO dose-dependently inhibited osteoclastogenesis from RANKL-stimulated mouse BMMs via decreasing the expression of NFATc1 and c-Fos. (C) 2016 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Xu Xiaohan,Liu Ning,Wang Yingjian, et al. Tatarinan O, a lignin-like compound from the roots of Acorus tatarinowii Schott inhibits osteoclast differentiation through suppressing the expression of c-Fos and NFATc1 [J].INTERNATIONAL IMMUNOPHARMACOLOGY,2016,34:212-219.
APA：

Xu Xiaohan,Liu Ning,Wang Yingjian,Pan Lei-chang,&Sun Wan-chun.(2016).Tatarinan O, a lignin-like compound from the roots of Acorus tatarinowii Schott inhibits osteoclast differentiation through suppressing the expression of c-Fos and NFATc1 .INTERNATIONAL IMMUNOPHARMACOLOGY,34:212-219.
MLA：

Xu Xiaohan, et al. "Tatarinan O, a lignin-like compound from the roots of Acorus tatarinowii Schott inhibits osteoclast differentiation through suppressing the expression of c-Fos and NFATc1" .INTERNATIONAL IMMUNOPHARMACOLOGY 34(2016):212-219.
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