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Improvement of Cisplatin-induced renal dysfunction by Schisandra chinensis stems via anti-inflammation and anti-apoptosis effects 期刊论文

编号：

052be05d-c8ed-4332-b60b-c08c86a556da
作者：

Li, YanZi#^[1]Ren, Shen^[1];Yan, XiaoTong^[1];Li, HuiPing^[1];Li, Wei^[1];Zheng, Bing^[2];Wang, Zi*^[1]Liu, YingYing(刘盈盈)*^[3]
语种：

英文
期刊：

JOURNAL OF ETHNOPHARMACOLOGY ISSN：0378-8741 2018 年 217 卷 (228 - 237) ; MAY 10
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关键词：

SCE Cisplatin-induced nephrotoxicity Oxidative stress inflammation Apoptosis
摘要：

Edmopharmacological relevance: Schisandra chinensis (Turcz.) Baill is a frequently used traditional Chinese medicine, and modem pharmacological research has proven that S. chinensis has antioxidant, anti-hepatotoxity, anti-inflammatory, and anti-nephrotoxic effects. Cisplatin is widely used as antineoplastic drug at present, but the clinical application is limited owing to its nephrotoxicity.
Aim of the study: To demonstrate the renoprotective activity of the extract of the stems of S. chinensis (SCE) in mice established by cisplatin-triggering acute kidney injury (AKI). The possible molecular mechanism of nephroprotection exhibited by SCE was evaluated for the first time.
Materials and methods: Mice in SCE groups were pre-treated with SCE for 10 consecutive days, and on 7th day 1 h after final administration, following intraperitoneal injection of cisplatin with 20 mg/kg was treated to cisplatin group and SCE groups. On the 10th day, renal function, histopathological change, and oxidative stress markers were investigated.
Results: Renal oxidative stress level characterized by elevated heme oxygenase 1 (HO-1), cytochrome P450 El (CYP2E1) and 4-hydroxynonenal (4-HNE) expression was obviously reduced by SCE pre-treatment. In addition, SCE was found to suppress inflammatory response through the reduction of nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) expression and nuclear factor-kappa B (NF-kappa B) p65 activation. SCE treatment also inhibited activation of apoptotic pathways through down-regulating Bax, cleaved caspase-3, 8, 9 and up-regulating Bcl-2 expression levels.
Conclusion: These findings illustrated that SCE possessed powerful protective effect on AKI caused by cisplatin via amelioration of oxidative stress, inflammation and apoptosis.
推荐引用方式
GB/T 7714：

Li Yan-Zi,Ren Shen,Yan Xiao-Tong, et al. Improvement of Cisplatin-induced renal dysfunction by Schisandra chinensis stems via anti-inflammation and anti-apoptosis effects [J].JOURNAL OF ETHNOPHARMACOLOGY,2018,217:228-237.
APA：

Li Yan-Zi,Ren Shen,Yan Xiao-Tong,Li Hui-Ping,&Liu Ying-Ying.(2018).Improvement of Cisplatin-induced renal dysfunction by Schisandra chinensis stems via anti-inflammation and anti-apoptosis effects .JOURNAL OF ETHNOPHARMACOLOGY,217:228-237.
MLA：

Li Yan-Zi, et al. "Improvement of Cisplatin-induced renal dysfunction by Schisandra chinensis stems via anti-inflammation and anti-apoptosis effects" .JOURNAL OF ETHNOPHARMACOLOGY 217(2018):228-237.
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