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Indocyanine Green-Loaded Gold Nanoflowers@Two Layers of Silica Nanocomposites for Photothermal and Photodynamic Therapy of Oral Carcinoma 期刊论文

编号：

07bb2e6b-73f3-406e-a46e-e254e04cc79d
作者：

Song, Wenzhi(宋文植)#^[1]Li, Yingzi(李英姿)^[1]Wang, Yuqian(王玉倩)^[2]Wang, Dezhou(汪德州)^[1]He, Dan^[3];Chen, Wei^[5];Yin, Wanzhong(尹万忠)*^[3]Yang, Wensheng(杨文胜)*^[4]
语种：

英文
期刊：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY ISSN：1550-7033 2017 年 13 卷 9 期 (1115 - 1123) ; DEC
收录：
关键词：

Indocyanine Green Photodynamic Therapy Photothermal Therapy Near-Infrared Light Gold Nanoflowers Nanocomposites
摘要：

Both photothermal therapy (PTT) and photodynamic therapy (PDT) are phototherapeutic approaches, which have been widely investigated for cancer therapy mediated by near infrared (NIR) light irradiation. Here, we successfully constructed a single-light triggered indocyanine green (ICG)-loaded gold nanocomposites which were composed of gold nanoflower core/two layers silica shell (AuNFs@SiO2@mSiO(2)-ICG) for enhanced PDT/PTT synergistic effect to oral carcinoma. The AuNFs@SiO2@mSiO(2)-ICG nanocomposites had no obviously cytotoxicity and could effectively arrest Cal27 cells in the G1 phase. Moreover, the conjugation of ICG caused significantly higher reactive oxygen species (ROS) productivity and apoptotic Cal27 cells compared to free ICG or free AuNFs@SiO2@mSiO(2). In this study, compared with PTT or PDT alone, synchronous PTT and PDT produced by AuNFs@SiO2@mSiO(2)-ICG under NIR light irradiation induced enhanced Cal27 cells lethality in vitro and tumor growth inhibition in vivo, which might be a promising strategy for cancer treatment.
推荐引用方式
GB/T 7714：

Song Wenzhi,Li Yingzi,Wang Yuqian, et al. Indocyanine Green-Loaded Gold Nanoflowers@Two Layers of Silica Nanocomposites for Photothermal and Photodynamic Therapy of Oral Carcinoma [J].JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2017,13(9):1115-1123.
APA：

Song Wenzhi,Li Yingzi,Wang Yuqian,Wang Dezhou,&Yang Wensheng.(2017).Indocyanine Green-Loaded Gold Nanoflowers@Two Layers of Silica Nanocomposites for Photothermal and Photodynamic Therapy of Oral Carcinoma .JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,13(9):1115-1123.
MLA：

Song Wenzhi, et al. "Indocyanine Green-Loaded Gold Nanoflowers@Two Layers of Silica Nanocomposites for Photothermal and Photodynamic Therapy of Oral Carcinoma" .JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 13,9(2017):1115-1123.
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