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miR-129-5p and-3p co-target WWP1 to suppress gastric cancer proliferation and migration 期刊论文

编号：

0e687a7e-27cc-4a8e-aba3-3629fe8f6b72
作者：

Ma, Lianjun(马连君)#*^[1]Chen, Xiaorui#^[2]Li, Chang(李畅)#^[3]Cheng, Rongjie^[2];Gao, Zhuo(高卓)^[1]Meng, Xiangbo(孟祥博)^[1]Sun, Chen(孙晨)^[1]Liang, Chenxi^[2];Liu, Yanqing*^[2]
语种：

英文
期刊：

JOURNAL OF CELLULAR BIOCHEMISTRY ISSN：0730-2312 2019 年 120 卷 5 期 (7527 - 7538) ; MAY
收录：
关键词：

gastric cancer (GC) microRNA (miRNA) miR-129-5p miR-129-3p WW domain-containing E3 ubiquitin protein ligase 1 (WWP1)
摘要：

Gastric cancer (GC) is a worldwide health problem. Uncovering the underlining molecular mechanisms of GC is of vital significance. Here, we identified a novel oncogene WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) in GC. WWP1 could promote GC cell proliferation and migration in vitro and expedite GC growth in vivo. We also found out two microRNAs (miRNAs): miR-129-5p and -3p could both target WWP1. Interestingly, miR-129-5p bound to the CDS region of WWP1 mRNA. The miR-129 pairs (miR-129-5p and -3p) play pivotal roles in GC to suppress its proliferation and migration in vitro and slow down GC growth in vivo by repressing WWP1. In summary, we identified two tumor suppressive miRNAs which share the same precursor that could regulate the same oncogene WWP1 in GC. Our finding would add new route for GC research and treatment.
推荐引用方式
GB/T 7714：

Ma Lianjun,Chen Xiaorui,Li Chang, et al. miR-129-5p and-3p co-target WWP1 to suppress gastric cancer proliferation and migration [J].JOURNAL OF CELLULAR BIOCHEMISTRY,2019,120(5):7527-7538.
APA：

Ma Lianjun,Chen Xiaorui,Li Chang,Cheng Rongjie,&Liu Yanqing.(2019).miR-129-5p and-3p co-target WWP1 to suppress gastric cancer proliferation and migration .JOURNAL OF CELLULAR BIOCHEMISTRY,120(5):7527-7538.
MLA：

Ma Lianjun, et al. "miR-129-5p and-3p co-target WWP1 to suppress gastric cancer proliferation and migration" .JOURNAL OF CELLULAR BIOCHEMISTRY 120,5(2019):7527-7538.
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