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Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 期刊论文

编号：

0edc8f60-50c6-4259-9e55-cfa001526fcd
作者：

Wang, Yonggang(王永刚)#^[1,2]Wu, Hao(吴昊)*^[3]Xin, Ying(辛颖)^[2,4]Bai, Yang^[2,5];Kong, Lili(孔莉莉)^[2,6]Tan, Yi^[2,7];Liu, Feng(刘锋)*^[8]Cai, Lu(蔡露)*^[2,7]
语种：

英文
期刊：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY ISSN：1942-0900 2017 年 2017 卷
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摘要：

Although angiotensin II (Ang II) was reported to facilitate spermmotility and intratesticular spermtransport, recent findings shed light on the efficacy of Ang II in stimulating inflammatory events in testicular peritubular cells, effect of which may play a role in male infertility. It is still unknown whether Ang II can induce testicular apoptotic cell death, which may be a more direct action of Ang II in male infertility. Therefore, the present study aims to determine whether Ang II can induce testicular apoptotic cell death and whether this action can be prevented by sulforaphane (SFN) via activating nuclear factor (erythroid-derived 2)-like 2 (NRF2), the governor of antioxidant-redox signalling. Eight-week-old male C57BL/6J wild type (WT) and Nrf2 gene knockout mice were treated with Ang II, in the presence or absence of SFN. In WT mice, SFN activated testicular NRF2 expression and function, along with amarked attenuation in Ang II-induced testicular oxidative stress, inflammation, endoplasmic reticulum stress, and apoptotic cell death. Deletion of the Nrf2 gene led to a complete abolishment of these efficacies of SFN. The present study indicated that Ang II may result in testicular apoptotic cell death, which can be prevented by SFN via the activation of NRF2.
推荐引用方式
GB/T 7714：

Wang Yonggang,Wu Hao,Xin Ying, et al. Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 [J].OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2017,2017.
APA：

Wang Yonggang,Wu Hao,Xin Ying,Bai Yang,&Cai Lu.(2017).Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2 .OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2017.
MLA：

Wang Yonggang, et al. "Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2" .OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2017(2017).
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