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Anesthetic drug propofol inhibits the expression of interleukin-6, interleukin-8 and cyclooxygenase-2, a potential mechanism for propofol in suppressing tumor development and metastasis 期刊论文

编号：

14f0fe62-2772-4377-a8c0-48d6586b8ba5
作者：

Li, Xuefeng(李学锋)#^[1]Li, Longyun(李龙云)^[1]Liang, Feng(梁枫)^[1]Liu, Guifeng(刘桂锋)*^[2]Zhao, Guoqing(赵国庆)*^[1]
语种：

英文
期刊：

ONCOLOGY LETTERS ISSN：1792-1074 2018 年 15 卷 6 期 (9523 - 9528) ; JUN
收录：
关键词：

anesthesia drug propofol interleukin-6 interleukin-8 cyclooxygenase-2 antitumor mechanism
摘要：

Previous studies have indicated that anesthesia-associated drugs may directly inhibit cellular immunity and humoral immunity, which may be associated with tumor recurrence. The present study demonstrated that propofol may suppress the proliferation of MCF-7 cells and inhibit the expression of interleukin (IL)-6 and IL-8. Subsequent to treatment with propofol, MCF-7 cells demonstrated downregulated cyclooxygenase-2 (COX-2) protein expression and decreased levels of vascular endothelial growth factor and prostaglandin E2 in the supernatant. Therefore, the mechanism of propofol in suppressing tumor development and metastasis may be associated with the inhibition of IL-6, IL-8 and COX-2.
推荐引用方式
GB/T 7714：

Li Xuefeng,Li Longyun,Liang Feng, et al. Anesthetic drug propofol inhibits the expression of interleukin-6, interleukin-8 and cyclooxygenase-2, a potential mechanism for propofol in suppressing tumor development and metastasis [J].ONCOLOGY LETTERS,2018,15(6):9523-9528.
APA：

Li Xuefeng,Li Longyun,Liang Feng,Liu Guifeng,&Zhao Guoqing.(2018).Anesthetic drug propofol inhibits the expression of interleukin-6, interleukin-8 and cyclooxygenase-2, a potential mechanism for propofol in suppressing tumor development and metastasis .ONCOLOGY LETTERS,15(6):9523-9528.
MLA：

Li Xuefeng, et al. "Anesthetic drug propofol inhibits the expression of interleukin-6, interleukin-8 and cyclooxygenase-2, a potential mechanism for propofol in suppressing tumor development and metastasis" .ONCOLOGY LETTERS 15,6(2018):9523-9528.
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