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Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase 期刊论文

编号：

167d8b92-ff0c-4021-a746-b2275326b3b7
作者：

Ma, Zhiming(马志明)#^[1]Wen, Dacheng^[1];Wang, Xudong^[1];Yang, Longfei(杨龙飞)^[2]Liu, Tianzhou^[1];Liu, Jingjing(刘晶晶)^[1]Zhu, Jiaming(朱甲明)*^[1]Fang, Xuedong(房学东)*^[1,3]
语种：

英文
期刊：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH ISSN：1943-8141 2016 年 8 卷 2 期 (1164 - 1171) ; 2016
收录：
关键词：

Adenocarcinoma apoptosis AMP-activated protein kinase calcium/calmodulin-dependent protein kinase kinase-beta gastric carcinoma short hairpin RNA
摘要：

Adenosine monophosphate (AMP)-activated protein kinase is a recently identified downstream target of calcium/calmodulin-dependent protein kinase kinase-beta, and is involved in the regulation of cell metabolism and cell proliferation. STO-609 is a selective antagonist of calcium/calmodulin-dependent protein kinase kinase-beta. In the present study, we found that STO-609 suppressed AMP-activated protein kinase activity, reduced expression of Akt and ERK, and increased cell apoptosis in SNU-1 and N87 cells but not normal gastric epithelial cells (CCL-241). Interestingly, we found such effects of STO-609 on gastric cancer cells were not affected after the knock-down of CaMKK-beta and AMPK. In conclusion, STO-609 is an effective cytotoxic agent for gastric adenocarcinoma in vivo.
推荐引用方式
GB/T 7714：

Ma Zhiming,Wen Dacheng,Wang Xudong, et al. Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase [J].AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2016,8(2):1164-1171.
APA：

Ma Zhiming,Wen Dacheng,Wang Xudong,Yang Longfei,&Fang Xuedong.(2016).Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase .AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,8(2):1164-1171.
MLA：

Ma Zhiming, et al. "Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase" .AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 8,2(2016):1164-1171.
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