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Synthesis of cell adhesive motif RGD tripeptide by a novel chemical method and its purification 期刊论文

编号：

1cdc874b-2b77-4cee-a167-4723c489900d
作者：

Wang Hua(王华)#; Zhao Mifeng;Ma Chengyun(马成云); Jing Wei;Huang Yibing(黄宜兵); Hou Ruizhen(侯瑞珍); Zeng Hongbin;Xu Li*; Zhang Xuezhong(张学忠)*;
语种：

英文
期刊：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES ISSN：1005-9040 2006 年 22 卷 5 期 (612 - 616) ; SEP
收录：
关键词：

RGD tripeptide chemical synthesis purification
摘要：

The cell adhesive motif RGD tripeptide was synthesized by using a novel chemical method. First, Gly-Asp (GD) was synthesized in two steps including the chloroacetylation of free L-aspartic acid and the ammonolysis of the chloroacetylated L-aspartic acid. The yield of chloroacetylated L-aspartic acid was 83.0%. For the ammonolysis of chloroacetylated L-aspartic acid, the yield of the ammonolyzed product was 92.3%. Second, the coupling. between Arg and Gly-Asp was carried out by using the NCA method. The maximum yield of RGD was about 50% at 0 degrees C and pH = 9.5. The prepared RGD tripeptide was confirmed by using amino acid component analysis and mass spectrographic analysis.
推荐引用方式
GB/T 7714：

Wang Hua,Zhao Mi-feng,Ma Cheng-yun, et al. Synthesis of cell adhesive motif RGD tripeptide by a novel chemical method and its purification [J].CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2006,22(5):612-616.
APA：

Wang Hua,Zhao Mi-feng,Ma Cheng-yun,Jing Wei,&Zhang Xue-zhong.(2006).Synthesis of cell adhesive motif RGD tripeptide by a novel chemical method and its purification .CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,22(5):612-616.
MLA：

Wang Hua, et al. "Synthesis of cell adhesive motif RGD tripeptide by a novel chemical method and its purification" .CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 22,5(2006):612-616.
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