Gold nanoflower-double layer silica core-shell nanoparticles were prepared by a seed-mediated growth strategy and a modified Stober method. The photothermal properties and the biotoxicity in vivo of the as-prepared core-shell nanoparticles were studied. The nude mice bearing oral cancer cell CAL27 were taken as the animal model to investigate the distribution, metabolism and passive targeting enrichment of the core-shell nanoparticles in vivo by the photoacoustic imaging technique. The results showed that the as-prepared core-shell nanoparticles exhibited excellent photothermal conversion properties in near infrared (NIR) region. The core-shell nanoparticles could be well metabolized in the liver, and could be excreted outside of the body through the intestinal tract. More importantly, the core-shell nanoparticles exhibited passive targeting enrichment in the tumor tissue through EPR effect. Our study show that the gold nanoflower-double layer silica core-shell nanoparticles would be an ideal photoacoustic imaging agent and a NIR photothermal therapy agent 14 diagnose and therapy of malignant tumors such as oral cancer.
[1]Jilin Univ, Clin Hosp 1, Changchun 130021, Jilin, Peoples R China.
[2]Jilin Univ, China Japan Union Hosp, Changchun 130031, Jilin, Peoples R China.
[3]Jilin Univ, Coll Chem, Changchun 130012, Jilin, Peoples R China.
(8.0+极速模式)