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Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-kappa B pathway 期刊论文

编号：

2b7be9b3-e1ba-4bcf-b180-2063d65f3e1f
作者：

Zhao, Zhongyan#^[1]Gong, Shilin^[2];Wang, Shumin*^[1,3]Ma, Chunhua*^[1,3]
语种：

英文
期刊：

INTERNATIONAL IMMUNOPHARMACOLOGY ISSN：1567-5769 2015 年 28 卷 1 期 (588 - 595) ; SEP
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关键词：

Evodiamine Ethanol Gastric ulcer Rho
摘要：

Evodiamine (EVD), a major alkaloid compound extracted from the dry unripened fruit Evodia fructus (Evodia rutaecarpa Benth., Rutaceae), has various pharmacological effects. The purpose of the present study was to investigate the possible anti-ulcerogenic potential of EVD and explore the underlying mechanism against ethanol-induced gastric ulcer in mice. Administration of EVD at the doses of 20,40 mg/kg body weight prior to the ethanol ingestion could effectively protect the stomach from ulceration. The gastric lesion was significantly ameliorated in the EVD group compared with that in the model group. Pre-treatment with EVD prevented the oxidative damage and decreased the levels of prostaglandin E2 (PGE2) content, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). In addition, EVD pretreatment markedly increased the serum levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT), decreased malonaldehyde (MDA) content in serum and activity of myeloperoxidase (MPO) in stomach tissues compared with those in the model group. In the mechanistic study, significant elevation of Rho, Rho-kinase 1 (ROCK1), ROCK2, cytosolic and nucleic NF-kappa Bp65 expressions were observed in the gastric mucosa group, whereas EVD effectively suppressed the protein expressions of Rho, Rho-kinase 1 (ROCK1), ROCK2, cytosolic and nucleic NF-kappa Bp65 in mice. Moreover, EVD showed protective activity on ethanol-induced GES-1 cells, while the therapeutic effects were not due to its cytotoxity. Taken together, these results strongly indicated that EVD exerted a gastro-protective effect against gastric ulceration. The underlying mechanism might be associated with the improvement of antioxidant and anti-inflammatory status through Rho/NF-kappa B pathway. (C) 2015 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Zhao Zhongyan,Gong Shilin,Wang Shumin, et al. Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-kappa B pathway [J].INTERNATIONAL IMMUNOPHARMACOLOGY,2015,28(1):588-595.
APA：

Zhao Zhongyan,Gong Shilin,Wang Shumin,Ma Chunhua.(2015).Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-kappa B pathway .INTERNATIONAL IMMUNOPHARMACOLOGY,28(1):588-595.
MLA：

Zhao Zhongyan, et al. "Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-kappa B pathway" .INTERNATIONAL IMMUNOPHARMACOLOGY 28,1(2015):588-595.
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