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Serum Unsaturated Free Fatty Acids: A Potential Biomarker Panel for Early-Stage Detection of Colorectal Cancer 期刊论文

编号：

2f29ebca-afc8-4911-8583-526f9c832b5f
作者：

Zhang, Yaping#^[1,2]He, Chengyan(何成彦)^[3]Qiu, Ling^[4,5];Wang, Yanmin^[6];Qin, Xuzhen^[4,5];Liu, Yujie^[1,2];Li, Zhili(李智立)*^[1,2]
语种：

英文
期刊：

JOURNAL OF CANCER ISSN：1837-9664 2016 年 7 卷 4 期 (477 - 483) ; 2016
收录：
关键词：

unsaturated free fatty acids biomarker panel early detection serum colorectal cancer
摘要：

Background:To screen biomarkers to differentiate early-stage colorectal cancer (CRC) from benign colorectal disease (BCD) and healthy controls.
Materials & Methods:Quantitative and qualitative analysis of C16:1, C18:3, C18:2, C18:1, C20:4, and C22:6 in 185 healthy controls, 55 patients with BCD, and 139 patients with CRC was performed. Comparisons of their levels in between CRC patients, BCD patients, and healthy controls were performed using Mann-Whitney U test.
Results:Serum levels of C16:1, C18:3, C18:2, C18:1, C20:4, and C22:6 in CRC patients were significantly decreased compared with healthy controls and BCD patients. A combination of C16:1, C18:2, C20:4, and C22:6 has excellent diagnostic performance to differentiate early-stage CRC patients from healthy controls plus BCD patients, with an AUC of 0.926, a sensitivity of 84.6%, and a specificity of 89.8%.
Conclusions:Serum levels of C16:1, C18:2, C20:4, and C22:6 could be diagnostic indicators of early-stage CRC patients.
推荐引用方式
GB/T 7714：

Zhang Yaping,He Chengyan,Qiu Ling, et al. Serum Unsaturated Free Fatty Acids: A Potential Biomarker Panel for Early-Stage Detection of Colorectal Cancer [J].JOURNAL OF CANCER,2016,7(4):477-483.
APA：

Zhang Yaping,He Chengyan,Qiu Ling,Wang Yanmin,&Li Zhili.(2016).Serum Unsaturated Free Fatty Acids: A Potential Biomarker Panel for Early-Stage Detection of Colorectal Cancer .JOURNAL OF CANCER,7(4):477-483.
MLA：

Zhang Yaping, et al. "Serum Unsaturated Free Fatty Acids: A Potential Biomarker Panel for Early-Stage Detection of Colorectal Cancer" .JOURNAL OF CANCER 7,4(2016):477-483.
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