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Intestinal Transport and Biotransformation of Resibufogenin and Cinobufagin in Chan Su via HPLC/APCI-MSn 期刊论文

编号：

34eced84-29cd-4e3e-931d-44676f12d9c7
作者：

Han Tianjiao#^[1,4]Wang Qing(王清)^[2]Song Fengrui^[1];Liu Zhongying^[3];Liu Zhiqiang(刘志强)*^[1]Liu Shuying^[1];
语种：

英文
期刊：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES ISSN：1005-9040 2011 年 27 卷 3 期 (380 - 384) ; MAY
收录：
关键词：

Chan Su Resibufogenin Cinobufagin Caco-2 cell monolayer Human intestinal bacteria
摘要：

In vitro models of human colon carcinoma cell line(Caco-2 cell monolayer) and human intestinal bacteria were used to investigate the intestinal transport and biotransformation of resibufogenin and cinobufagin in Chan Su by HPLC/APCI-MSn. The experimental results of Caco-2 cell monolayer demonstrate that the apparent permeability coefficients(P-app) of resibufogenin and cinobufagin are higher than 10(-6) cm/s, which indicates that both resibufogenin and cinobufagin have a good absorption in the small intestine. And the biotransformation result of human intestinal bacteria shows that resibufogenin has been transformed to 3-epiresibufogenin and cinobufagin has been transformed to 3-epicinobufagin, deacetylcinobufagin and 3-epideacetycinobufagin, respectively.
推荐引用方式
GB/T 7714：

Han Tian-jiao,Wang Qing,Song Feng-rui, et al. Intestinal Transport and Biotransformation of Resibufogenin and Cinobufagin in Chan Su via HPLC/APCI-MSn [J].CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2011,27(3):380-384.
APA：

Han Tian-jiao,Wang Qing,Song Feng-rui,Liu Zhong-ying,&Liu Shu-ying.(2011).Intestinal Transport and Biotransformation of Resibufogenin and Cinobufagin in Chan Su via HPLC/APCI-MSn .CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,27(3):380-384.
MLA：

Han Tian-jiao, et al. "Intestinal Transport and Biotransformation of Resibufogenin and Cinobufagin in Chan Su via HPLC/APCI-MSn" .CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 27,3(2011):380-384.

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