Intracranial tumor is one of the most common diseases in nervous system, which has great harm to the function of human nervous system. Surgical tumor resection is the primary treatment method for the disease. Ultrasonoscopy is helpful for lesion localization and boundary determination in intracranial tumor resection surgery resection rate improvement and reduction of postoperative tumor recurrence probability. However, the deficiency of routine ultrasound examination in image contrast leads to obvious limitation thereof in clinical application. The blood perfusion difference between pathological tissue and normal tissue can be utilized to increase the image contrast in ultrasound contrast, thereby providing more accurate and clearer ultrasonic image, assisting the performer to determine tumor boundary more accurately, understand the hemoperfusion status of tumor, judge residual tumor, and improving diagnosis accuracy and surgical resection rate.