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PCT, CRP, Ang-2 expressions and SGRQ scores for assessing post-treatment health status of AECOPD patients 期刊论文

编号：

3796afc6-57dd-4793-b3a4-19ab314a5621
作者：

Zhao, Jianjun(赵建军)#^[1]Yu, Dujuan(于杜娟)^[1]Shi, Shaomin(石少敏)^[1]Li, Ning(李宁)^[1]Wang, Jing(王静)^[1]Yang, Lei*^[1]
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY ISSN：1936-2625 2016 年 9 卷 7 期 (6804 - 6812) ; 2016
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关键词：

PCT CRP Ang-2 SGRQ AECOPD patients treatment effect
摘要：

Background and aim: Our study is aimed at clarifying the interrelationship among PCT, CRP, Ang-2 and SGRQ in post-treatment patients with AECOPD. This study also confirmed that whether or not PCT, CRP, Ang-2 and SGRQ are appropriate biomarkers for assessing the efficacy of AECOPD treatments. Material and methods: The case group incorporated 88 patients with AECOPD and another 40 patients with stable-stage COPD admitted in our hospital during the period between April 2015 and October 2015. We also recruited a total of 50 healthy individuals as the control group in order to carry out this case-control study. All patients in the case group have received conventional symptomatic treatments. Serum samples were collected from all study subjects for detecting PCR, CRP and Ang-2 expressions. Meanwhile, the Saint George"s respiratory questionnaire was specifically designed to assess and quantify the health status and life wellbeing of all individuals who participated in this study. Statistical analysis was carried out using the SPSS 19.0 statistical software. Results: PCT, CRP and Ang-2 expression levels were all increased in COPD patients compared to normal people. Furthermore, PCT, CRP and Ang-2 expression levels in AECOPD patients were much higher than those in stable-stage COPD patients (all P < 0.05). PCT, CRP and Ang-2 expression levels in the better group appeared to be gradually decreased as time of treatment increased. By contrast, Ang-2, PCT and CRP expression levels were increased in the worse group as time of treatment increased (all P < 0.05). Results from statistical analysis indicated that both CRP and PCT expression levels were positively correlated with Ang-2 expression. As suggested by correlation analysis, PCT, CRP and Ang-2 expression levels were closely related to the health status and wellbeing of patients with AECOPD. Conclusion: Serum PCT, CRP and Ang-2 are effective biomarkers of acute exacerbated COPD and they can be used to determine the severity of COPD as well as the effectiveness of treatments on AECOPD.
推荐引用方式
GB/T 7714：

Zhao Jianjun,Yu Dujuan,Shi Shaomin, et al. PCT, CRP, Ang-2 expressions and SGRQ scores for assessing post-treatment health status of AECOPD patients [J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2016,9(7):6804-6812.
APA：

Zhao Jianjun,Yu Dujuan,Shi Shaomin,Li Ning,&Yang Lei.(2016).PCT, CRP, Ang-2 expressions and SGRQ scores for assessing post-treatment health status of AECOPD patients .INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,9(7):6804-6812.
MLA：

Zhao Jianjun, et al. "PCT, CRP, Ang-2 expressions and SGRQ scores for assessing post-treatment health status of AECOPD patients" .INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 9,7(2016):6804-6812.
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