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ultrasound imaging guided tumor photodynamic therapy 期刊论文

编号：

42c3bf62-cb11-4832-b9d1-1bbe75341244
作者：

Gao, Shi(高识)#^[1]Wang, Guohao#^[2,3]Qin, Zainen^[2,3];Wang, Xiangyu^[2,3];Zhao, Guoqing*^[1]Ma, Qingjie(马庆杰)*^[1]Zhu, Lei(朱雷)*^[2,3,4]
语种：

英文
期刊：

BIOMATERIALS ISSN：0142-9612 2017 年 112 卷 (324 - 335) ; JAN
收录：
关键词：

Hypoxia Oxygen generating Image-guided therapy Photodynamic therapy Hyaluronic acid particles Manganese dioxide nanoparticles
摘要：

Photodynamic therapy (PDT) is a promising tumor treatment modality that can convert oxygen into cytotoxic singlet oxygen (SO) via photosensitizer to ablate tumor growth. However, the uncontrolled cancer cell proliferation during tumor development and the oxygen consumption during PDT always result in an insufficient oxygen level in tumors, which can adversely affect the PDT efficiency in turn. We designed an oxygen-generating PDT nanocomplex by encapsulating a manganese dioxide nanoparticle (MnO2 NP) in an indocyanine green (ICG) modified hyaluronic acid nanoparticle (HANP) to overcome this limitation. Because of the excellent fluorescent and photoacoustic properties, the tumor accumulation of the ICG-HANP/MnO2 (IHM) nanocomplex was monitored by fluorescent imaging and photoacoustic imaging after intravenous administration into the SCC7 tumor-bearing mouse model. Both high fluorescent and photoacoustic signals were detected and found peak at 6 h post-injection (tumor-muscle ratio: 4.03 +/- 0.36 for fluorescent imaging and 2.93 +/- 0.13 for photoacoustic imaging). In addition, due to the high reactivity of MnO2 NP to H2O2, an unfavorable tumor cell metabolic, the oxygen content in the tumor is elevated 2.25 +/- 0.07 times compared to that without IHM treatment as ultrasound imaging confirmed. After laser irradiation, significant tumor growth inhibition was observed in the IHM-treated group compared to the ICG-HANP-treated group, attributed to the beneficial oxygen-generating property of IHM for PDT. It is expected that the design of IHM will provide an alternative way of improving clinical PDT efficacy and will be widely applied in cancer theranostics. (C) 2016 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Gao Shi,Wang Guohao,Qin Zainen, et al. Oxygen-generating hybrid nanoparticles to enhance fluorescent/photoacoustic/ultrasound imaging guided tumor photodynamic therapy [J].BIOMATERIALS,2017,112:324-335.
APA：

Gao Shi,Wang Guohao,Qin Zainen,Wang Xiangyu,&Zhu Lei.(2017).Oxygen-generating hybrid nanoparticles to enhance fluorescent/photoacoustic/ultrasound imaging guided tumor photodynamic therapy .BIOMATERIALS,112:324-335.
MLA：

Gao Shi, et al. "Oxygen-generating hybrid nanoparticles to enhance fluorescent/photoacoustic/ultrasound imaging guided tumor photodynamic therapy" .BIOMATERIALS 112(2017):324-335.
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