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RAGE Expression in Tumor-Associated Macrophages Promotes Angiogenesis in Glioma 期刊论文

编号：

43976e71-db27-4af5-8c99-c667e5c9fa01
作者：

Chen, Xuebo(陈学博)#^[1]Zhang, Leying#^[2]Zhang, Ian Y.^[2];Liang, Junling^[3];Wang, Huaqing^[4];Ouyang, Mao^[5];Wu, Shihua^[3];Carvalho da Fonseca, Anna Carolina^[6,7];Weng, Lihong^[8];Yamamoto, Yasuhiko^[9];Yamamoto, Hiroshi^[9];Natarajan, Rama^[10];Badie, Behnam*^[2,11]
语种：

英文
期刊：

CANCER RESEARCH ISSN：0008-5472 2014 年 74 卷 24 期 (7285 - 7297) ; DEC 15
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摘要：

Interaction of RAGE (the receptor for advanced glycation endproducts) with its ligands can promote tumor progression, invasion, and angiogenesis. Although blocking RAGE signaling has been proposed as a potential anticancer strategy, functional contributions of RAGE expression in the tumor microenvironment (TME) have not been investigated in detail. Here, we evaluated the effect of genetic depletion of RAGE in TME on the growth of gliomas. In both invasive and noninvasive glioma models, animal survival was prolonged in RAGE knockout (Ager(-/-)) mice. However, the improvement in survival in Ager(-/-) mice was not due to changes in tumor growth rate but rather to a reduction in tumor-associated inflammation. Furthermore, RAGE ablation in the TME abrogated angiogenesis by downregulating the expression of proangiogenic factors, which prevented normal vessel formation, thereby generating a leaky vasculature. These alterations were most prominent in noninvasive gliomas, in which the expression of VEGF and proinflammatory cytokines were also lower in tumor-associated macrophages (TAM) in Ager(-/-) mice. Interestingly, reconstitution of Ager(-/-) TAM with wild-type microglia or macrophages normalized tumor vascularity. Our results establish that RAGE signaling in glioma-associated microglia and TAM drives angiogenesis, underscoring the complex role of RAGE and its ligands in gliomagenesis.
推荐引用方式
GB/T 7714：

Chen Xuebo,Zhang Leying,Zhang Ian Y., et al. RAGE Expression in Tumor-Associated Macrophages Promotes Angiogenesis in Glioma [J].CANCER RESEARCH,2014,74(24):7285-7297.
APA：

Chen Xuebo,Zhang Leying,Zhang Ian Y.,Liang Junling,&Badie Behnam.(2014).RAGE Expression in Tumor-Associated Macrophages Promotes Angiogenesis in Glioma .CANCER RESEARCH,74(24):7285-7297.
MLA：

Chen Xuebo, et al. "RAGE Expression in Tumor-Associated Macrophages Promotes Angiogenesis in Glioma" .CANCER RESEARCH 74,24(2014):7285-7297.
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