首页 / 院系成果 / 成果详情页

Sequential Drug Release and Enhanced Photothermal and Photoacoustic Effect of Hybrid Reduced Graphene Oxide-Loaded Ultrasmall Gold Nanorod Vesicles for Cancer Therapy

  • 编号:
    469fac22-f46e-424e-8836-39ca9251a04e
  • 作者:
    Song, Jibin(songjibin)#[1,2] Yang, Xiangyu[2] Jacobson, Orit[2] Lin, Lisen[2] Huang, Peng[2] Niu, Gang[2] Ma, QingJie(马庆杰)*[1] Chen, Xiaoyuan(chenxiaoyuan)*[2]
  • 语种:
    英文
  • 期刊:
    ACS NANO ISSN:1936-0851 2015 年 9 卷 9 期 (9199 - 9209) ; SEP
  • 收录:
  • 关键词:
  • 摘要:

    We report a hybrid reduced graphene oxide (rGO)-loaded ultrasmall plasmonic gold nanorod vesicle (rGO-AuNRVe) (similar to 65 nm in size) with remarkably amplified photoacoustic (PA) performance and photothermal effects. The hybrid vesicle also exhibits a high loading capacity of doxorubicin (DOX), as both the cavity of the vesicle and the large surface area of the encapsulated rGO can be used for loading DOX, making it an excellent drug carrier. The loaded DOX is released sequentially: near-infrared photothermal heating induces DOX release from the vesicular cavity, and an intracellular acidic environment induces DOX release from the rGO surface. Positron emission tomography imaging showed high passive U87MG tumor accumulation of Cu-64-labeled rGO-AuNRVes (similar to 9.7% ID/g at 24 h postinjection) and strong PA signal in the tumor region. Single intravenous injection of rGO-AuNRVe-DOX followed by low-power-density 808 nm laser In Veto Sequential Drug Release irradiation (0.25 W/cm(2)) revealed effective inhibition of tumor growth due to the combination of chemo- and photothermal therapies. The rGO-AuNRVe-DOX capable of sequential DOX release by laser light and acid environment may have the potential for clinical translation to treat cancer patients with tumors accessible by light.

  • 推荐引用方式
    GB/T 7714:
    Song Jibin,Yang Xiangyu,Jacobson Orit, et al. Sequential Drug Release and Enhanced Photothermal and Photoacoustic Effect of Hybrid Reduced Graphene Oxide-Loaded Ultrasmall Gold Nanorod Vesicles for Cancer Therapy [J].ACS NANO,2015,9(9):9199-9209.
  • APA:
    Song Jibin,Yang Xiangyu,Jacobson Orit,Lin Lisen,&Chen Xiaoyuan.(2015).Sequential Drug Release and Enhanced Photothermal and Photoacoustic Effect of Hybrid Reduced Graphene Oxide-Loaded Ultrasmall Gold Nanorod Vesicles for Cancer Therapy .ACS NANO,9(9):9199-9209.
  • MLA:
    Song Jibin, et al. "Sequential Drug Release and Enhanced Photothermal and Photoacoustic Effect of Hybrid Reduced Graphene Oxide-Loaded Ultrasmall Gold Nanorod Vesicles for Cancer Therapy" .ACS NANO 9,9(2015):9199-9209.
  • 条目包含文件:
    文件类型:PDF,文件大小:
    正在加载全文
浏览次数:490 下载次数:0
浏览次数:490
下载次数:0
打印次数:0
浏览器支持: Google Chrome   火狐   360浏览器极速模式(8.0+极速模式) 
返回顶部