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Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery 期刊论文

编号：

49a36023-9174-4a39-b4ec-6aacb7e2bf83
作者：

Zhou, Dongfang(周东方)#^[2]Xiao, Haihua^[2];Meng, Fanbo(孟繁波)*^[1]Zhou, Shaoyang^[3];Guo, Jinshan^[2];Li, Xiaoyuan^[2];Jing, Xiabin(景遐斌)^[2]Huang, Yubin*^[2]
语种：

英文
期刊：

BIOCONJUGATE CHEMISTRY ISSN：1043-1802 2012 年 23 卷 12 期 (2335 - 2343) ; DEC
收录：
摘要：

Platinum(IV), a pro-drug of platinum(II), was conjugated to poly(L-lysine) (PLL), and then assembled with poly(glutamic acid) (PGA) through a layer-by-layer (LbL) approach on colloidal silica templates. After removal of the templates, biodegradable PGA/PLL-Pt(IV) multilayer capsules (diameter = 0.5 mu m) with 10 mu g of platinum incorporated into each bilayer were obtained. Under acidic and/or reductive conditions, the amount and rate of platinum released from the capsules were increased, which are desirable traits for platinum-based anticancer drug delivery systems. Furthermore, in vitro evaluation showed that the PGA/PLL-Pt(IV) multilayer microcapsule's displayed higher cytotoxicity (IC50Pt = 3.5 mu g/mL) against colon cancer cells CT-26 than that of free cisplatin (IC50Pt = 8.6 mu g/mL). This enhanced cytotoxicity was attributed to the effective internalization of the capsules by the cancer cells, which was observed by confocal laser scanning microscopy (CLSM) imaging.
推荐引用方式
GB/T 7714：

Zhou Dongfang,Xiao Haihua,Meng Fanbo, et al. Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery [J].BIOCONJUGATE CHEMISTRY,2012,23(12):2335-2343.
APA：

Zhou Dongfang,Xiao Haihua,Meng Fanbo,Zhou Shaoyang,&Huang Yubin.(2012).Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery .BIOCONJUGATE CHEMISTRY,23(12):2335-2343.
MLA：

Zhou Dongfang, et al. "Layer-by-Layer Assembled Polypeptide Capsules for Platinum-Based Pro-Drug Delivery" .BIOCONJUGATE CHEMISTRY 23,12(2012):2335-2343.
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