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MicroRNA-384 Inhibits the Growth and Invasion of Renal Cell Carcinoma Cells by Targeting Astrocyte Elevated Gene 1  期刊论文  

  • 编号:
    5291edff-7c5a-40c6-862d-4e955a617d1a
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  • 语种:
    英文
  • 期刊:
    ONCOLOGY RESEARCH ISSN:0965-0407 2018 年 26 卷 3 期 (457 - 466)
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  • 摘要:

    MicroRNAs (miRNAs) are emerging as pivotal regulators in the development and progression of various cancers, including renal cell carcinoma (RCC). MicroRNA-384 (miR-384) has been found to be an important cancer-related miRNA in several types of cancers. However, the role of miR-384 in RCC remains unclear. In this study, we aimed to investigate the potential function of miR-384 in regulating tumorigenesis in RCC. Here we found that miR-384 was significantly downregulated in RCC tissues and cell lines. Overexpression of miR-384 significantly inhibited the growth and invasion of RCC cells. whereas inhibition of miR-384 had the opposite effects. Bioinformatic analysis and luciferase reporter assay showed that naiR-384 directly targeted the 3'-untranslated region of astrocyte elevated gene 1 (AEG-1). Further data showed that miR-384 could negatively regulate the expression of AEG-1 in RCC cells. Importantly, miR-384 expression was inversely correlated with AEG-1 expression in clinical RCC specimens. Moreover, miR-384 regulates the activation of Wnt signaling. Overexpression of AEG-1 significantly reversed the antitumor effects of miR-384. Overall, these findings suggest that miR-384 suppresses the growth and invasion of RCC cells via downregulation of AEG-1. providing a potential therapeutic target for the treatment of RCC.

  • 推荐引用方式
    GB/T 7714:
    Song Haitao,Rao Yanwei,Zhang Gang, et al. MicroRNA-384 Inhibits the Growth and Invasion of Renal Cell Carcinoma Cells by Targeting Astrocyte Elevated Gene 1 [J].ONCOLOGY RESEARCH,2018,26(3):457-466.
  • APA:
    Song Haitao,Rao Yanwei,Zhang Gang,Kong Xiangbo.(2018).MicroRNA-384 Inhibits the Growth and Invasion of Renal Cell Carcinoma Cells by Targeting Astrocyte Elevated Gene 1 .ONCOLOGY RESEARCH,26(3):457-466.
  • MLA:
    Song Haitao, et al. "MicroRNA-384 Inhibits the Growth and Invasion of Renal Cell Carcinoma Cells by Targeting Astrocyte Elevated Gene 1" .ONCOLOGY RESEARCH 26,3(2018):457-466.
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