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MicroRNA-mediated Silencing of RhoC Inhibits Tumor Invasion and Increases Chemosensitivity to Paclitaxel in SKOV3 Cells in vitro 期刊论文

编号：

59420e5d-d7f3-48a7-ae37-2d18432e34c3
作者：

Pan Ying(潘颖)#^[1]Du Zhenwu(杜珍武)^[1]Leng Weichun(冷维春)^[1]Zhou Jiawen(周家文)^[1]Wang Yingjian(王瑛坚)#^[1]Sheng Minjia(盛敏佳)^[1]Wang Junrong(王俊容)^[1]Zhang Guizhen(张桂珍)*^[1]
语种：

英文
期刊：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES ISSN：1005-9040 2011 年 27 卷 1 期 (70 - 74) ; JAN 25
收录：
关键词：

RhoC gene miRNA SKOV3 cell Cell invasion Paclitaxel
摘要：

RhoC is a member of the Ras-homologous family of genes which are implicated in tumorigenesis and tumor progression. Up-regulation of RhoC is associated with tumor progression in ovarian carcinoma and RhoC is significantly correlated with the invasive capability of ovarian cancer cell lines in vitro. We developed a system that blocks RhoC in the human ovarian cancer SKOV3 cells using specific MicroRNA(miRNA) interference. By transfecting SKOV3 cells with the plasmid vector to express specific MiRNA that targets human RhoC, we were able to establish a stable clone in which RhoC expression was significantly downregulated. This resulted in the decreased invasive potential of SKOV3 cells as well as increased chemosensitivity to paclitaxel. RhoC involves in invasion and chemosensitivity of SKOV3, indicating that RhoC may be a promising therapeutic target for ovarian cancer.
推荐引用方式
GB/T 7714：

Pan Ying,Du Zhen-wu,Leng Wei-chun, et al. MicroRNA-mediated Silencing of RhoC Inhibits Tumor Invasion and Increases Chemosensitivity to Paclitaxel in SKOV3 Cells in vitro [J].CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2011,27(1):70-74.
APA：

Pan Ying,Du Zhen-wu,Leng Wei-chun,Zhou Jia-wen,&Zhang Gui-zhen.(2011).MicroRNA-mediated Silencing of RhoC Inhibits Tumor Invasion and Increases Chemosensitivity to Paclitaxel in SKOV3 Cells in vitro .CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,27(1):70-74.
MLA：

Pan Ying, et al. "MicroRNA-mediated Silencing of RhoC Inhibits Tumor Invasion and Increases Chemosensitivity to Paclitaxel in SKOV3 Cells in vitro" .CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 27,1(2011):70-74.

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