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ACTN4 and the pathways associated with cell motility and adhesion contribute to the process of lung cancer metastasis to the brain 期刊论文

编号：

62117a21-26bc-48b9-9f0f-ecd4101207c6
作者：

Gao, Yufei(高宇飞)#^[1]Li, Guanghu(李光虎)#^[2]Sun, Liankun^[3];He, Yichun^[1]Li, Xiaoyan(李小燕)^[4]Sun, Zhi(孙志)^[5]Wang, Jihan(王冀邯)^[3]Jiang, Yang(姜洋)*^[6]Shi, Jingwei(时景伟)*^[5]
语种：

英文
期刊：

BMC CANCER ISSN：1471-2407 2015 年 15 卷 ; APR 12
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关键词：

ACTN4 Cytoskeleton organization Metastasis Lung cancer Brain tumor
摘要：

Background: The aim of this study was to identify critical gene pathways that are associated with lung cancer metastasis to the brain.
Methods: The RNA-Seq approach was used to establish the expression profiles of a primary lung cancer, adjacent benign tissue, and metastatic brain tumor from a single patient. The expression profiles of these three types of tissues were compared to define differentially expressed genes, followed by serial-cluster analysis, gene ontology analysis, pathway analysis, and knowledge-driven network analysis. Reverse transcription-polymerase chain reaction (RT-PCR) was used to validate the expression of essential candidate genes in tissues from ten additional patients.
Results: Differential gene expression among these three types of tissues was classified into multiple clusters according to the patterns of their alterations. Further bioinformatic analysis of these expression profile data showed that the network of the signal transduction pathways related to actin cytoskeleton reorganization, cell migration, and adhesion was associated with lung cancer metastasis to the brain. The expression of ACTN4 (actinin, alpha 4), a cytoskeleton protein gene essential for cytoskeleton organization and cell motility, was significantly elevated in the metastatic brain tumor but not in the primary lung cancer tissue.
Conclusions: The signaling pathways involved in the regulation of cytoskeleton reorganization, cell motility, and focal adhesion play a role in the process of lung cancer metastasis to the brain. The contribution of ACTN4 to the process of lung cancer metastasis to the brain could be mainly through regulation of actin cytoskeleton reorganization, cell motility, and focal adhesion.
推荐引用方式
GB/T 7714：

Gao Yufei,Li Guanghu,Sun Liankun, et al. ACTN4 and the pathways associated with cell motility and adhesion contribute to the process of lung cancer metastasis to the brain [J].BMC CANCER,2015,15.
APA：

Gao Yufei,Li Guanghu,Sun Liankun,He Yichun,&Shi Jingwei.(2015).ACTN4 and the pathways associated with cell motility and adhesion contribute to the process of lung cancer metastasis to the brain .BMC CANCER,15.
MLA：

Gao Yufei, et al. "ACTN4 and the pathways associated with cell motility and adhesion contribute to the process of lung cancer metastasis to the brain" .BMC CANCER 15(2015).
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