首页 / 院系成果 / 成果详情页

Candidate Biomarkers and Molecular Mechanism Investigation for Glioblastoma Multiforme Utilizing WGCNA 期刊论文

编号：

63cedb07-e536-40cc-a0c2-cdaaadf04f93
作者：

Yang, Qi(杨琦)#^[1]Wang, Rui(王睿)^[2]Wei, Bo(韦博)^[3]Peng, Chuangang(彭传刚)^[4]Wang, Le^[5];Hu, Guozhang(胡国章)^[6]Kong, Daliang(孔大亮)^[7]Du, Chao(杜超)*^[3]
语种：

英文
期刊：

BIOMED RESEARCH INTERNATIONAL ISSN：2314-6133 2018 年 2018 卷
收录：
摘要：

To reveal the potential molecular mechanism of glioblastoma multiforme (GBM) and provide the candidate biomarkers for GBM gene therapy. Microarray dataset GSE50161 was obtained from GEO database. The differentially expressed genes (DEGs) were identified between GBM samples and control samples, followed by the module partition analysis based on WGCNA. Then, the pathway and functional enrichment analyses of DEGs were performed. The hub genes were further investigated, followed by the survival analysis and data validation. A total of 1913 DEGs were investigated between two groups, followed by analysis of 5 modules using WGCNA. These DEGs were mainly enriched in functions like inflammatory response. The hub genes including upregulated N-Myc and STAT Interactor (NMI), Capping Actin Protein-Gelsolin Like (CAPG), and Proteasome Subunit Beta 8 (PSMB8) were revealed as potential liquid biopsy molecules for GBM diagnose. Moreover, Nucleolar and Spindle Associated Protein 1 (NUSAPI) and G Protein-Coupled Receptor 65 (GPR65) were outstanding genes in survival analysis. Our results suggested that CPNE6, HAPLN2, CMTM3, NMI, CAPG, and PSMB8 might be used as potential molecules for liquid biopsy of G BM. NUSA PI and G P R65 might be novel prognostic targets for GBM gene therapy. Furthermore, the upregulated NMI might play an important role in GBM progression via inflammatory response.
推荐引用方式
GB/T 7714：

Yang Qi,Wang Rui,Wei Bo, et al. Candidate Biomarkers and Molecular Mechanism Investigation for Glioblastoma Multiforme Utilizing WGCNA [J].BIOMED RESEARCH INTERNATIONAL,2018,2018.
APA：

Yang Qi,Wang Rui,Wei Bo,Peng Chuangang,&Du Chao.(2018).Candidate Biomarkers and Molecular Mechanism Investigation for Glioblastoma Multiforme Utilizing WGCNA .BIOMED RESEARCH INTERNATIONAL,2018.
MLA：

Yang Qi, et al. "Candidate Biomarkers and Molecular Mechanism Investigation for Glioblastoma Multiforme Utilizing WGCNA" .BIOMED RESEARCH INTERNATIONAL 2018(2018).
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：38  下载次数：0

分享到：

浏览次数：38

下载次数：0

打印次数：0