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Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells 期刊论文

编号：

672ae9bf-924d-491c-83da-ee5384ab1792
作者：

Yi, Heqing(易贺庆)#^[1]Liang, Bing^[1];Jia, Jie(贾杰)^[2]Liang, Nan^[1];Xu, Huiying^[1];Ju, Guizhi^[1];Ma, Shumei(马淑梅)*^[1]Liu, Xiaodong*^[1,3]
语种：

英文
期刊：

FEBS LETTERS ISSN：0014-5793 2013 年 587 卷 5 期 (436 - 443) ; MAR 1
收录：
关键词：

MiR-199a-5p DRAM1 Beclin1 Autophagy Irradiation
摘要：

Autophagy is a self-degrading process that is triggered by diverse stimuli including ionizing radiation. In this study we show novel phenomena in which transfection of miR-199a-5p mimic significantly suppresses IR-induced autophagy in MCF7 cells, and up-regulates basal and IR-induced autophagy in MDA-MB-231 breast cancer cells. We also identify DRAM1 and Beclin1 as novel target genes for miR-199a-5p. Overexpression of miR-199a-5p inhibits DRAM1 and Beclin1 expression in MCF7 cells, while it enhances expression of these genes in MDA-MB-231 cells. Furthermore, we show that miR-199a-5p sensitizes MDA-MB-231 cells to irradiation. Therefore, our data identify miR-199a-5p as a novel and unique regulator of autophagy, which plays an important role in cancer biology and cancer therapy. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Yi Heqing,Liang Bing,Jia Jie, et al. Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells [J].FEBS LETTERS,2013,587(5):436-443.
APA：

Yi Heqing,Liang Bing,Jia Jie,Liang Nan,&Liu Xiaodong.(2013).Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells .FEBS LETTERS,587(5):436-443.
MLA：

Yi Heqing, et al. "Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells" .FEBS LETTERS 587,5(2013):436-443.
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