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Synthesis and Evaluation of a Biocompatible Macromolecular Gadolinium Compound as a Liver-Specific Contrast Agent for MRI 期刊论文

编号：

71d57127-2216-4e30-8aa9-32af687a82c4
作者：

Zhan, Youyang#^[1,2]Xue, Rong^[1];Zhang, Mengchao(张孟超)^[3]Wan, Chuanling^[1,2];Li, Xiaojing*^[1]Pei, Fengkui^[1];Sun, Changjiang(孙长江)^[3]Liu, Lin(柳林)^[3]
语种：

英文
期刊：

AUSTRALIAN JOURNAL OF CHEMISTRY ISSN：0004-9425 2017 年 70 卷 3 期 (307 - 313) ; 2017
收录：
摘要：

A new macromolecular biocompatible gadolinium chelate complex (PAI-N-2-DOTA-Gd) as a liver-specific magnetic resonance imaging (MRI) contrast agent was synthesised and evaluated. An aspartic acid-isoleucine copolymer was chemically linked with Gd-DOTA via ethylenediamine to give PAI-N-2-DOTA-Gd. In vitro, the T-1-relaxivity of PAI-N-2-DOTA-Gd (14.38mmol(-1)Ls(-1), 0.5 T) was much higher than that of the clinically used Gd-DOTA (4.96mmol(-1)Ls(-1), 0.5 T), with obvious imaging signal enhancement. In the imaging experiments in vivo, PAI-N-2-DOTA-Gd exhibited good liver selectivity, and had a greater intensity enhancement (68.8 +/- 5.6%) and a longer imaging window time (30-70min), compared to Gd-DOTA (21.1 +/- 5.3%, 10-30min). Furthermore, the in vivo histological studies of PAI-N-2-DOTA-Gd showed a low acute toxicity and desirable biocompatibility. The results of this study indicate that PAI-N-2-DOTA-Gd is a feasible liver-specific contrast agent for MRI.
推荐引用方式
GB/T 7714：

Zhan Youyang,Xue Rong,Zhang Mengchao, et al. Synthesis and Evaluation of a Biocompatible Macromolecular Gadolinium Compound as a Liver-Specific Contrast Agent for MRI [J].AUSTRALIAN JOURNAL OF CHEMISTRY,2017,70(3):307-313.
APA：

Zhan Youyang,Xue Rong,Zhang Mengchao,Wan Chuanling,&Liu Lin.(2017).Synthesis and Evaluation of a Biocompatible Macromolecular Gadolinium Compound as a Liver-Specific Contrast Agent for MRI .AUSTRALIAN JOURNAL OF CHEMISTRY,70(3):307-313.
MLA：

Zhan Youyang, et al. "Synthesis and Evaluation of a Biocompatible Macromolecular Gadolinium Compound as a Liver-Specific Contrast Agent for MRI" .AUSTRALIAN JOURNAL OF CHEMISTRY 70,3(2017):307-313.
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