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Antitumor activity of mHSP65-TTL enhanced by administration of low dose cyclophosphamide in pancreatic cancer-bearing mice 期刊论文

编号：

72172a60-6248-4d9a-aad9-93a76e3bc250
作者：

Xuan, Wei(宣巍)#^[1]Yan, Youyou^[2];Wan, Min(万敏)^[3]Wu, Xiuli(吴秀丽)^[3]Ji, Degang(季德刚)^[1]Wang, Liying^[3];Lin, Chao(林超)^[1]Chen, Yang^[1];Yu, Yongli(于永利)*^[2]Zhang, Xuewen(张学文)*^[1]
语种：

英文
期刊：

INTERNATIONAL IMMUNOPHARMACOLOGY ISSN：1567-5769 2015 年 27 卷 1 期 (95 - 103) ; JUL
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关键词：

mHSP65 Cyclophosphamide Tumor lysates Th17 cells Pancreatic cancer
摘要：

Pancreatic cancer remains a lethal malignancy. Despite chemotherapy or/and radiotherapy after the surgery, the improvement on the overall survival of the patients has still been minimal. To develop novel therapeutic approaches, we tried to prepare mHSP65-TTL, a candidate vaccine prepared by mixing the recombinant mycobacterial heat shock protein 65 (mHSP65) with tumor tissue lysate (TTL) of Panc02 pancreatic cancer tissue. The mHSP65-TTL were used to immune the C57BL/6 mice implanted with the Panc02 cancer cells, in combination with or without low dose cyclophosphamide (CY). The results showed that mHSP65-ITL significantly prolonged the survival of the pancreatic cancer bearing mice and low dose CY enhanced the efficacy of the mHSP65-TTL. In addition, we detected mRNA expression of ROR gamma t and IL-17A in spleen cells of mice received mHSP65-ITL or mHSP65-TTL plus CY, and found that mHSP65-TTL up-regulated mRNA expressions of ROR gamma t and IL-17A, CY alone or mHSP65-TTL plus CY up-regulated mRNA expressions of ROR gamma t. The work could provide an insight into a combinational approach for the immunotherapy of pancreatic cancer. (C) 2015 Published by Elsevier B.V.
推荐引用方式
GB/T 7714：

Xuan Wei,Yan Youyou,Wan Min, et al. Antitumor activity of mHSP65-TTL enhanced by administration of low dose cyclophosphamide in pancreatic cancer-bearing mice [J].INTERNATIONAL IMMUNOPHARMACOLOGY,2015,27(1):95-103.
APA：

Xuan Wei,Yan Youyou,Wan Min,Wu Xiuli,&Zhang Xuewen.(2015).Antitumor activity of mHSP65-TTL enhanced by administration of low dose cyclophosphamide in pancreatic cancer-bearing mice .INTERNATIONAL IMMUNOPHARMACOLOGY,27(1):95-103.
MLA：

Xuan Wei, et al. "Antitumor activity of mHSP65-TTL enhanced by administration of low dose cyclophosphamide in pancreatic cancer-bearing mice" .INTERNATIONAL IMMUNOPHARMACOLOGY 27,1(2015):95-103.
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