Recently, there is increasing evidence that microRNAs are related to the development, diagnosis, treatment, and prognosis of glioblastoma. microRNA-210 (miR-210) had been identified in many human cancers, but the specific function of miR-210 remains unclear in glioblastoma. The present study mainly focused on exploring its biological role and potential molecular mechanisms in glioblastoma. We found that miR-210 expression was decreased in glioblastoma, and downregulation of miR-210 was related to worse prognosis in glioblastoma patients. In addition, miR-210 overexpression inhibited the migration and invasion of human glioblastoma cells. At the same time, we found that miR-210 directly targets the brain-derived neurotrophic factor (BDNF) and reduces BDNF expression level. Consistently, BDNF silencing had the same effects as miR-210 overexpression in glioblastoma, and upregulation of BDNF counteracted the inhibitory effect of miR-210 in glioblastoma. In conclusion, miR-210 suppressed the migration and invasion of glioblastoma cells by targeting BDNF.
[1]Jilin Univ, Dept Neurosurg, Hosp 2, Changchun, Jilin, Peoples R China.
[2]Jilin Univ, Dept Vasc Surg, China Japan Union Hosp, Changchun, Jilin, Peoples R China.
[3]Jilin Univ, Dept Pediat, China Japan Union Hosp, Changchun, Jilin, Peoples R China.
[4]Jilin Univ, Dept Neurosurg, China Japan Union Hosp, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China.
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