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Hsa-miR-137, hsa-miR-520e and hsa-miR-590-3p perform crucial roles in Lynch syndrome 期刊论文

编号：

80b5d454-8c12-4b48-b621-4775b6e6e83d
作者：

Zhou, Changyu(周长玉)#^[1]Li, Jiayu(李佳彧)*^[2]Li, Jiarui^[3];Wan, Yingchun(宛迎春)^[4]Li, Tao(李涛)^[5]Ma, Piyong(马丕勇)^[6]Wang, Yingjian(王瑛坚)^[7]Sang, Haiyan(桑海燕)^[2]
语种：

英文
期刊：

ONCOLOGY LETTERS ISSN：1792-1074 2016 年 12 卷 3 期 (2011 - 2017) ; SEP
收录：
关键词：

Lynch syndrome differentially expressed miRNA target gene regulatory network
摘要：

The aim of the present study was to identify the differentially expressed microRNAs (DEMs) between Lynch syndrome (LS) and the normal colonic (N-C) control samples, predict the target genes (TGs) and analyze the potential functions of the DEMs and TGs. The miRNA expression dataset GSE30454, which included data of 13 LS and 20 N-C tissue samples, was downloaded from the Gene Expression Omnibus. The classical t-test in Linear Models for Microarray Data package was used for DEM identification. TG prediction was performed using 5 databases. The regulatory network of the DEMs and their TGs was constructed using Cytoscape. Functional and pathway enrichment analysis was performed. The transcription factors (TFs), tumor-associated genes (TAG) and tumor suppressor genes (TSGs) were then identified. Three key DEMs hsa-miR-137, hsa-miR-520e, and hsa-miR-590-3p were identified. Hsa-miR-520e and hsa-miR-137 had 4 common TGs, including SNF related kinase, metal-regulatory transcription factor 1 (MTF1), round spermatid basic protein 1 and YTH N6-methyladenosine RNA binding protein 3; hsa-miR-590-3p and hsa-miR-137 had 14 common TGs, including NCK adaptor protein 1 (NCK1), EPH receptor A7, and stressassociated endoplasmic reticulum protein 1; hsa-miR-590-3p and hsa-miR-520e had 12 common TGs, including Kruppel-like factor (KLF) 13, twinfilin actin binding protein 1, and nuclear factor I B. Through the functional and pathway enrichments analysis, MTF1 was involved in regulation of gene expression and metabolic processes, and sequence-specific DNA binding TF activity. KLF13 was involved in regulation of gene expression and regulation of cellular metabolic processes. NCK1 was enriched in the axon guidance pathway. In addition, the functional and pathway enrichment analysis showed certain TGs, such as hypoxia-inducible factor 1 alpha, AKT serine/threonine kinase 2, and rapamycin-insensitive companion of mammalian target of rapamycin, participated in the mTOR signaling pathway. The 3 key DEMs hsa-miR-137, hsa-miR-520e, and hsa-miR-590-3p may have important roles in the process of LS.
推荐引用方式
GB/T 7714：

Zhou Changyu,Li Jiayu,Li Jiarui, et al. Hsa-miR-137, hsa-miR-520e and hsa-miR-590-3p perform crucial roles in Lynch syndrome [J].ONCOLOGY LETTERS,2016,12(3):2011-2017.
APA：

Zhou Changyu,Li Jiayu,Li Jiarui,Wan Yingchun,&Sang Haiyan.(2016).Hsa-miR-137, hsa-miR-520e and hsa-miR-590-3p perform crucial roles in Lynch syndrome .ONCOLOGY LETTERS,12(3):2011-2017.
MLA：

Zhou Changyu, et al. "Hsa-miR-137, hsa-miR-520e and hsa-miR-590-3p perform crucial roles in Lynch syndrome" .ONCOLOGY LETTERS 12,3(2016):2011-2017.
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