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Salvage interstitial brachytherapy based on computed tomography for recurrent cervical cancer after radical hysterectomy and adjuvant radiation therapy: case presentations and introduction of the technique 期刊论文

编号：

81bf2519-d2dd-4e68-951b-426f0bb39e9b
作者：

Liu, ZhongShan#^[1]Guo, Jie^[1];Zhao, YangZhi^[2];Lin, Xia^[1];Chen, Bin(陈滨)^[3]Zhang, Ming^[4];Li, JiangMing^[5];Ren, XiaoJun^[1];Zhang, BingYa^[1];Wang, TieJun*^[1]
语种：

英文
期刊：

JOURNAL OF CONTEMPORARY BRACHYTHERAPY ISSN：1689-832X 2016 年 8 卷 5 期 (415 - 421) ; 2016
收录：
关键词：

cervical cancer computed tomography interstitial brachytherapy recurrence
摘要：

Purpose: Locally recurring cervical cancer after surgery and adjuvant radiotherapy remains a major therapeutic challenge. This paper presents a new therapeutic technique for such patients: interstitial brachytherapy (BT) guided by real-time three-dimensional (3D) computed tomography (CT).
Material and methods: Sixteen patients with recurrent cervical cancer after radical surgery and adjuvant external- beam radiotherapy (EBRT) were included in this study. These patients underwent high-dose-rate (HDR) interstitial BT with free-hand placement of metal needles guided by real-time 3D-CT. Six Gy in 6 fractions were prescribed for the high-risk clinical target volume (HR-CTV). D-90 and D-100 for HR-CTV of BT, and the cumulative D-2cc for the bladder, rectum, and sigmoid, including previous EBRT and present BT were analyzed. Treatment-related complications and 3-month tumor-response rates were investigated.
Results: The mean D-90 value for HR-CTV was 52.5 +/- 3.3 Gy. The cumulative D-2cc for the bladder, rectum, and sigmoid were 85.6 +/- 5.8, 71.6 +/- 6.4, and 69.6 +/- 5.9 Gy, respectively. The mean number of needles was 6.1 +/- 1.5, with an average depth of 3.5 +/- 0.9 cm for each application. Interstitial BT was associated with minor complications and passable tumor-response rate.
Conclusions: Interstitial BT guided by real-time 3D-CT for recurrent cervical cancer results in good dose-volume histogram (DVH) parameters. The current technique may be clinically feasible. However, long-term clinical outcomes should be further investigated.
推荐引用方式
GB/T 7714：

Liu Zhong-Shan,Guo Jie,Zhao Yang-Zhi, et al. Salvage interstitial brachytherapy based on computed tomography for recurrent cervical cancer after radical hysterectomy and adjuvant radiation therapy: case presentations and introduction of the technique [J].JOURNAL OF CONTEMPORARY BRACHYTHERAPY,2016,8(5):415-421.
APA：

Liu Zhong-Shan,Guo Jie,Zhao Yang-Zhi,Lin Xia,&Wang Tie-Jun.(2016).Salvage interstitial brachytherapy based on computed tomography for recurrent cervical cancer after radical hysterectomy and adjuvant radiation therapy: case presentations and introduction of the technique .JOURNAL OF CONTEMPORARY BRACHYTHERAPY,8(5):415-421.
MLA：

Liu Zhong-Shan, et al. "Salvage interstitial brachytherapy based on computed tomography for recurrent cervical cancer after radical hysterectomy and adjuvant radiation therapy: case presentations and introduction of the technique" .JOURNAL OF CONTEMPORARY BRACHYTHERAPY 8,5(2016):415-421.
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