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Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells 期刊论文

编号：

8cafce81-6679-4e1e-9dc9-684d12e044f9
作者：

Xue, LongXing(薛龙星)#^[1]Xu, ZhongHang^[2];Wang, JiaoQi(王姣琦)^[1]Cui, Yang(崔杨)^[1]Liu, Hong Yu(刘洪雨)^[1]Liang, WenZhao(梁文昭)^[1]Ji, QiuYe(纪秋野)^[3]He, JinTing(何金婷)^[1]Shao, YanKun(邵延坤)^[1]Mang, Jing(莽靖)*^[1]Xu, ZhongXin(徐忠信)*^[1]
语种：

英文
期刊：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN：0006-291X 2016 年 480 卷 3 期 (355 - 361) ; NOV 18
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关键词：

Activin A/Smads Autophagy JNK p38 Oxygen Glucose Deprivation (OGD)
摘要：

Activin A (Act A), a member of the transforming growth factor-beta (TGF-beta), reduces neuronal apoptosis during cerebral ischemia through Act A/Smads signaling pathway. However, little is known about the effect of Act A/Smads pathway on autophagy in neurons. Here, we found that oxygen-glucose deprivation (OGD)-induced autophagy was suppressed by exogenous Act A in a concentration-dependent manner and enhanced by Act A/Smads pathway inhibitor (ActRIIA-Ab) in neuronal PC12 cells. These results indicate that Act A/Smads pathway negatively regulates autophagy in OGD-treated PC12 cells. In addition, we found that c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways are involved in the OGD-induced autophagy. The activation of JNK and p38 MAPK pathways in OGD-treated PC12 cells was suppressed by exogenous Act A and enhanced by ActRIIA-Ab. Together, our results suggest that Act A/Smads signaling pathway negatively regulates OGD-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells. (C) 2016 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Xue Long-Xing,Xu Zhong-Hang,Wang Jiao-Qi, et al. Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells [J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016,480(3):355-361.
APA：

Xue Long-Xing,Xu Zhong-Hang,Wang Jiao-Qi,Cui Yang,&Xu Zhong-Xin.(2016).Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,480(3):355-361.
MLA：

Xue Long-Xing, et al. "Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells" .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 480,3(2016):355-361.
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