Objective: To analyze the clinical efficacy of autologous platelet-rich gel (APG) in the topical treatment of deep grade II burn wounds. Methods: Sixty-eight patients with deep grade II burn wounds were selected and divided into the treatment group and control group randomly and equally. The treatment group was treated with APG by wet application and the control group was treated with silvadene cream by external application. After one month of treatment, the differences between two groups were compared in healing time and ratio of healed area, the frequency of dressing changes, the positive rate of wound secretion bacterial culture and the scores of visual analogue scale (VAS). Besides, the levels of transforming growth factor beta 1 (TGF beta 1) and epidermal growth factor (EGF) in burn wound tissues, the scar grades and the adverse reactions were also compared between two groups. Results: Compared to control group, the healing time, ratio of healed area, frequency of dressing changes, the positive rate of wound secretion bacterial culture of in treatment group were reduced (all P<0.05). In addition, the scores of VAS and Vancouver scar scale (VSS) in treatment group were lower than those in control group (P<0.05). However, there was no significant difference in the incidence of adverse reactions between two groups (P>0.05). The levels of TGF beta 1 and EGF in burn wound tissue of treatment group were higher than those in control group (P<0.05). Conclusion: APG can effectively shorten the healing time, improve recovering rate, reduce frequency of dressing changes and the grade of wound pain, and then promote wound healing for patients with deep grade II burn wounds.
[1]Jilin Univ, Hosp 2, Orthoped Med Ctr, Changchun, Jilin, Peoples R China.
[2]Jilin Univ, China Japan Union Hosp, Dept Plast Surg, 126 Xiantai St, Changchun 130000, Jilin, Peoples R China.
(8.0+极速模式)