Nasal polyposis (NP) is characterized by chronic mucosal inflammation with infiltrating eosinophils. Eosinophil-mediated tissue remodeling may be involved in NP pathogenesis; therefore, improved understanding of tissue remodeling may result the identification of novel pathways and therapeutic strategies. The present study aimed to investigate the pathological changes occurring during tissue remodeling in NP, in order to assess the role of intercellular adhesion molecule-1 (ICAM-1) in localized tissue remodeling and the potential association between ICAM-1 expression and markers of eosinophil activation. A total of 28 eligible patients and 10 healthy controls participated in the current study. Nasal mucosal tissues of these subjects were retrospectively evaluated for mucosal remodeling using hi stopathological staining. ICAM-1 and eosinophil cationic protein (ECP) expression levels were determined by immunohistochemical analysis. Compared with the healthy controls, all the specimens from NP patients presented substantial epithelial damage, skewed cellular distribution with a reduced density of goblet cells, an increased density of subepithelial gland and increased subepithelial collagen deposition. In addition, the NP specimens exhibited significantly higher eosinophil infiltration and ICAM-1 expression compared with the controls. Positive correlations were observed between ICAM-1 and ECP expression levels (P=0.010), as well as between extracellular collagen deposition and ICAM-1 (P=0.010) and ECP (P=0.012) expression levels in the NP specimens, but not in the control specimens. Morphological evidence demonstrated eosinophil-mediated tissue remodeling in NP tissues. ICAM-1 expression in activated eosinophils was associated with NP remodeling, indicating the possibility that ICAM-1 may regulate NP remodeling.
[1]Jilin Univ, Dept Otorhinolaryngol Head & Neck Surg, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China.
[2]Jilin Univ, Dept Thyroid Surg, China Japan Union Hosp, Jilin Prov Key Lab Surg Translat Med, Changchun 130033, Jilin, Peoples R China.
[3]Changchun Obstet Gynecol Hosp, Dept Gynecol & Obstertr, Changchun 130042, Jilin, Peoples R China.
[4]Peoples Hosp Changchun, Dept Cerebral Surg, Changchun 130051, Jilin, Peoples R China.
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