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Conditioned Media from Deer Antler Stem Cells Effectively Alleviate Type 1 Diabetes Mellitus Possibly via Inhibiting the NF-κB Signaling Pathway. 期刊论文

编号：

D485E8FE33EC1EE3FD6DFE3EA8E67386
作者：

Wang Dongxu#^[1]Ren Jing^[2];Li Jiping^[1];Li Xiuying(李秀英)^[3]Ying Jinchi^[4];Jiang Tiantian^[4];Wang Zhen^[1];Pan Zheng^[3];Guo Qianqian^[1];Li Chunyi^[2];Zhang Guokun^[1];
地址：

[1]Institute of Antler Science and Product Technology, Changchun Sci-Tech University, 130600 Changchun, Jilin, China.
[2]Institute of Antler Science and Product Technology, Changchun Sci-Tech University, 130600 Changchun, Jilin, China.;College of Chinese Medicinal Materials, Jilin Agricultural University, 130118 Changchun, Jilin, China.
[3]Scientific Research center, China-Japan Union Hospital, Jilin University, 130033 Changchun, Jilin, China.
[4]College of Chinese Medicinal Materials, Jilin Agricultural University, 130118 Changchun, Jilin, China.
语种：

英文
期刊：

Frontiers in bioscience (Landmark edition) ISSN：2768-6698 2024 年 29 卷 3 期 (96 - ) ; 2024-Mar-11
收录：
关键词：

NF-κB signaling pathway conditioned medium deer antler stem cells liver injury type 1 diabetes mellitus
摘要：

Type 1 diabetes mellitus (T1D) represents a severe threat to human health. Persistent hyperglycemia and dyslipidemia can lead to damaged liver function, while effective interventions for these complications are currently lacking. Deer antler stem cells (AnSCs), a novel type of adult stem cells, significantly reduced liver injury, which was speculated to be achieved through the paracrine pathway.;In this study, AnSC-conditioned medium (AnSC-CM) was used to treat C57BL/6 mice with T1D symptoms induced by streptozotocin (STZ). The therapeutic effects of AnSC-CM on T1D were evaluated, and the underlying mechanism was investigated.;It was shown that AnSC-CM alleviated the T1D symptom: decreased body weight, increased blood glucose levels and islet lesions, and reduced insulin secretion. Moreover, AnSC-CM treatment improved liver function and mitigated liver injury in T1D mice. Impressively, the therapeutic effects of AnSC-CM on T1D were better than those of bone marrow mesenchymal stem cell-CM (BMSC-CM). The mechanistic study revealed that AnSC-CM significantly downregulated the NF-κB signaling pathway in both pancreatic and liver tissues.;Therapeutic effects of AnSC-CM on STZ-induced T1D and liver injury may be achieved through targeting the NF-κB signaling pathway.;
推荐引用方式
GB/T 7714：

Wang Dongxu,Ren Jing,Li Jiping, et al. Conditioned Media from Deer Antler Stem Cells Effectively Alleviate Type 1 Diabetes Mellitus Possibly via Inhibiting the NF-κB Signaling Pathway. [J].Frontiers in bioscience (Landmark edition),2024,29(3):96-.
APA：

Wang Dongxu,Ren Jing,Li Jiping,Li Xiuying,&Zhang Guokun.(2024).Conditioned Media from Deer Antler Stem Cells Effectively Alleviate Type 1 Diabetes Mellitus Possibly via Inhibiting the NF-κB Signaling Pathway. .Frontiers in bioscience (Landmark edition),29(3):96-.
MLA：

Wang Dongxu, et al. "Conditioned Media from Deer Antler Stem Cells Effectively Alleviate Type 1 Diabetes Mellitus Possibly via Inhibiting the NF-κB Signaling Pathway." .Frontiers in bioscience (Landmark edition) 29,3(2024):96-.

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