IL-2-loaded Polypeptide Nanoparticles for Enhanced Anti-cancer Immunotherapy

• 编号：
  E5E5E6835F79D2A978E3DD81E95E8558
• 作者：
  Wang, XiaoShuang^[1,2];Zheng, ZhaoShi(郑昭时)^[1]Zheng, MengFei^[2,4];Wang, Di^[1,2];Zhang, HongLei^[2,5,6];Zhang, ZhenQian^[2,5,6];Liu, ZhiLin^[2,3];Tang, ZhaoHui^[2,3,4];Han, XueMei(韩雪梅)*^[1]
• 语种：
  英文
• 期刊：
  CHINESE JOURNAL OF POLYMER SCIENCE ISSN：0256-7679 2023 年
• 收录：
   
• 关键词：
  Polypeptide Phenylboronic acid Boron-nitrogen coordination Interleukin 2 ROS-responsive
• 摘要：

  Interleukin 2 (IL-2) is widely used as an active immunotherapeutic agent in clinical metastatic cancers. However, its therapeutic concentrations do not last long due to its short half-life. Thus, only a transient proliferation of the anti-cancer CD8(+) T cells can be achieved, resulting in poor efficacy. Therefore, the aim of this work was to create a system that promotes CD8(+) T cell proliferation at the tumor site using IL-2 persistently present and activates an anti-cancer immune response. This goal was achieved by the design of the IL-2-loaded polypeptide nanoparticles (P-IL-2) where methoxy poly(ethylene glycol) block poly-[(N-2-hydroxyethyl)-aspartamide] phenylboronic acid was used to encapsulate IL-2 through boron-nitrogen coordination with poly((L)-lysine). P-IL-2 significantly prolonged the circulation time of IL-2 and achieved a selective drug release at the tumor site in the presence of high levels of reactive oxygen species, thus activating an anti-cancer immune response and exerting a better anti-cancer effect. The half-life of P-IL-2 was 3.15-fold higher than that of IL-2, and the quantity of CD8(+) T cells after using P-IL-2 was 1.89-fold higher than that after using IL-2. In addition, the combination of P-IL-2 and anti-CTLA-4 monoclonal antibody resulted in an enhanced immune activation. Hence, this work provides a new approach to improve the efficacy of IL-2 in anti-cancer immunotherapy.

• 推荐引用方式
  GB/T 7714：
  Wang Xiao-Shuang,Zheng Zhao-Shi,Zheng Meng-Fei, et al. IL-2-loaded Polypeptide Nanoparticles for Enhanced Anti-cancer Immunotherapy [J].CHINESE JOURNAL OF POLYMER SCIENCE,2023.
• APA：
  Wang Xiao-Shuang,Zheng Zhao-Shi,Zheng Meng-Fei,Wang Di,&Han Xue-Mei.(2023).IL-2-loaded Polypeptide Nanoparticles for Enhanced Anti-cancer Immunotherapy .CHINESE JOURNAL OF POLYMER SCIENCE.
• MLA：
  Wang Xiao-Shuang, et al. "IL-2-loaded Polypeptide Nanoparticles for Enhanced Anti-cancer Immunotherapy" .CHINESE JOURNAL OF POLYMER SCIENCE(2023).