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MicroRNA-145-3p suppresses proliferation and promotes apotosis and autophagy of osteosarcoma cell by targeting HDAC4 期刊论文

编号：

a0c13ce0-f73a-4ce2-b555-e0436f42302d
作者：

Wu, Guangzhi(吴广智)#^[1]Yu, Wei(于维)^[1]Zhang, Minglei(张明磊)*^[2]Yin, Ruofeng(尹若峰)*^[2]Wu, Yan^[3];Liu, Qiang^[3];
语种：

英文
期刊：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY ISSN：2169-1401 2018 年 46 卷 (579 - 586)
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关键词：

MiR-145-3p proliferation apoptosis autophagy HDAC4 osteosarcoma
摘要：

Studies have shown that miR-145-3p functions as a tumor suppressor and is associated with tumor growth and metastasis. This study intends to uncover the mechanism of a tumor suppressor of miR-145-3p. The expressions of miR-194 in osteosarcoma cell lines and tissues were monitored by real-time PCR. The proliferation ability was examined by MTT assay. The apoptosis and autophagy of cells were monitored by flow cytometry and microcopy, respectively. The regulation of miR-145-3p on HDAC4 was determined by luciferase assays and western blot assay. The results showed that miR-145-3p was significantly reduced in the osteosarcoma compared with the normal bone tissue. Overexpression of miR-145-3p significantly attenuated the proliferation and induced the apoptosis and autophagy of osteosarcoma cells. Furthermore, we demonstrated that miR-145-3p has inhibited the malignant behavior of osteosarcoma by down-regulating HDAC4 expression. These findings suggested that miR-145-3p may act as a tumor suppressor in osteosarcoma. MiR-145-3p/HDAC4 may be a novel therapeutic target in treatment of osteosarcoma.
推荐引用方式
GB/T 7714：

Wu Guangzhi,Yu Wei,Zhang Minglei, et al. MicroRNA-145-3p suppresses proliferation and promotes apotosis and autophagy of osteosarcoma cell by targeting HDAC4 [J].ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2018,46:579-586.
APA：

Wu Guangzhi,Yu Wei,Zhang Minglei,Yin Ruofeng,&Liu Qiang.(2018).MicroRNA-145-3p suppresses proliferation and promotes apotosis and autophagy of osteosarcoma cell by targeting HDAC4 .ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,46:579-586.
MLA：

Wu Guangzhi, et al. "MicroRNA-145-3p suppresses proliferation and promotes apotosis and autophagy of osteosarcoma cell by targeting HDAC4" .ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 46(2018):579-586.
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