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Cell Surface Sialylation and Fucosylation Are Regulated by L1 via Phospholipase C gamma and Cooperate to Modulate Neurite Outgrowth, Cell Survival and Migration 期刊论文

编号：

afef1143-c934-4557-b090-4331a35a98cd
作者：

Li, Yali#*^[1,2,3]Wu, Guangzhi(吴广智)^[1,4]Dawe, Gavin S.^[3];Zeng, Li^[5,6];Cui, Shusen(崔树森)^[4]Loers, Gabriele^[7];Tilling, Thomas^[7];Sun, Li^[2];Schachner, Melitta^[7,8];Xiao, ZhiCheng^[1,2,5];
语种：

英文
期刊：

PLOS ONE ISSN：1932-6203 2008 年 3 卷 12 期 ; DEC 2
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摘要：

Background: Cell surface glycosylation patterns are markers of cell type and status. However, the mechanisms regulating surface glycosylation patterns remain unknown.
Methodology/Principal Findings: Using a panel of carbohydrate surface markers, we have shown that cell surface sialylation and fucosylation were downregulated in L1(-/y) neurons versus L1(+/y) neurons. Consistently, mRNA levels of sialyltransferase ST6Gal1, and fucosyltransferase FUT9 were significantly reduced in L1(-/y) neurons. Moreover, treatment of L1(+/y) neurons with L1 antibodies, triggering signal transduction downstream of L1, led to an increase in cell surface sialylation and fucosylation compared to rat IgG-treated cells. ShRNAs for both ST6Gal1 and FUT9 blocked L1 antibody-mediated enhancement of neurite outgrowth, cell survival and migration. A phospholipase C gamma (PLC gamma) inhibitor and shRNA, as well as an Erk inhibitor, reduced ST6Gal1 and FUT9 mRNA levels and inhibited effects of L1 on neurite outgrowth and cell survival.
Conclusions: Neuronal surface sialylation and fucosylation are regulated via PLC gamma by L1, modulating neurite outgrowth, cell survival and migration.
推荐引用方式
GB/T 7714：

Li Ya-li,Wu Guang-zhi,Dawe Gavin S., et al. Cell Surface Sialylation and Fucosylation Are Regulated by L1 via Phospholipase C gamma and Cooperate to Modulate Neurite Outgrowth, Cell Survival and Migration [J].PLOS ONE,2008,3(12).
APA：

Li Ya-li,Wu Guang-zhi,Dawe Gavin S.,Zeng Li,&Xiao Zhi-Cheng.(2008).Cell Surface Sialylation and Fucosylation Are Regulated by L1 via Phospholipase C gamma and Cooperate to Modulate Neurite Outgrowth, Cell Survival and Migration .PLOS ONE,3(12).
MLA：

Li Ya-li, et al. "Cell Surface Sialylation and Fucosylation Are Regulated by L1 via Phospholipase C gamma and Cooperate to Modulate Neurite Outgrowth, Cell Survival and Migration" .PLOS ONE 3,12(2008).
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