In recent years, glucose-sensitive drug delivery systems have attracted considerable attention in the treatment of diabetes. These systems can regulate payload release by the changes of blood glucose levels continuously and automatically with potential application in self-regulated drug delivery. Boronic acid (BA), especially phenylboronic acid (PBA), as glucose-sensitive agent has been the focus of research in the design of glucose-sensitive platforms. This article reviews the previous attempts at the developments of PBA-based glucose-sensitive drug delivery systems regarding the PBA-functionalized materials and glucose-triggered drug delivery. The obstacles and potential developments of glucose-sensitive drug delivery systems based on PBA for diabetes treatment in the future are also described. The PBA-functionalized platforms that regulate drug delivery induced by glucose are expected to contribute significantly to the design and development of advanced intelligent self-regulated drug delivery systems for treatment of diabetes.
[1]Jilin Jianzhu Univ, Coll Mat Sci & Engn, Lab Bldg Energy Saving Technol Engn, Changchun 130118, Peoples R China.
[2]Jilin Univ, China Japan Union Hosp, Dept Endocrinol, Changchun 130033, Peoples R China.
[3]Changchun Univ Chinese Med, Affiliated Hosp 1, Dept Endocrine, Changchun 130117, Peoples R China.
[4]Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China.
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