首页 / 院系成果 / 成果详情页

Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in Apoe(-/-) mice with hyperhomocysteinemia 期刊论文

编号：

bf84dc90-c2bd-4f33-ba30-fa73d061cd8a
作者：

Li, Hongjun(李洪军)#^[1]He, Chengyan(何成彦)^[1]Wang, Jingying(王晶莹)^[1]Li, Xiaoou^[2];Yang, Zhaowei(杨照微)^[1]Sun, Xiaoying(孙晓盈)^[1]Fang, Ling^[1];Liu, Ning(刘宁)*^[3]
语种：

英文
期刊：

JOURNAL OF DIABETES INVESTIGATION ISSN：2040-1116 2016 年 7 卷 6 期 (824 - 832) ; NOV
收录：
关键词：

Atherosclerosis Berberine Peroxisome proliferator-activated receptor-
摘要：

Aims/IntroductionAn elevated level of plasma homocysteine has long been suspected as a metabolic risk factor for the development of atherosclerotic vascular diseases in diabetes. Berberine (BBR) has several preventive effects on cardiovascular diseases. The effects of BBR on atherosclerotic plaque stability increased by homocysteine thiolactone (HTL) remain unknown.
Materials and MethodsThe model of atherosclerotic vulnerable plaque was induced by placing a collar around the carotid artery in Apoe(-/-) mice. Endothelium-dependent relaxation was assayed by organ chamber.
ResultsHomocysteine thiolactone (50 mg/kg/day, 8 weeks) reduced the atherosclerotic plaque stability in the carotid artery of Apoe(-/-) mice, which was reversed by BBR administration (1.0 g/kg/day). In vivo and ex vivo experiments showed that HTL dramatically reduced acetylcholine-induced endothelium-dependent relaxation and superoxide dismutase activity, and increased malondialdehyde content, which were inhibited by BBR. Importantly, all effects induced by BBR were abolished by GW9662, an antagonist of peroxisome proliferator-activated receptor-. Incubation of cultured endothelial cells with HTL significantly reduced cell viabilities and enhanced production of reactive oxygen species. Pretreatment of cells with BBR dose-dependently reversed HTL-induced detrimental effects, which were GW9662-reversible.
ConclusionsBerberine increases atherosclerotic plaque stability in hyperhomocysteinemia mice, which is related to the activation of peroxisome proliferator-activated receptor- and subsequent suppression of oxidative stress in endothelial cells.
An elevated level of plasma homocysteine has long been suspected as a metabolic risk factor for the development of atherosclerotic vascular diseases in diabetes. We reported that berberine, as a natural production, increase atherosclerotic plaque stability in hyperhomocysteinaemia mice, which is related to the activation of PPAR and subsequent suppression of oxidative stress in endothelial cells.
推荐引用方式
GB/T 7714：

Li Hongjun,He Chengyan,Wang Jingying, et al. Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in Apoe(-/-) mice with hyperhomocysteinemia [J].JOURNAL OF DIABETES INVESTIGATION,2016,7(6):824-832.
APA：

Li Hongjun,He Chengyan,Wang Jingying,Li Xiaoou,&Liu Ning.(2016).Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in Apoe(-/-) mice with hyperhomocysteinemia .JOURNAL OF DIABETES INVESTIGATION,7(6):824-832.
MLA：

Li Hongjun, et al. "Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in Apoe(-/-) mice with hyperhomocysteinemia" .JOURNAL OF DIABETES INVESTIGATION 7,6(2016):824-832.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：24  下载次数：0

分享到：

浏览次数：24

下载次数：0

打印次数：0