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Relevance of anatomical, plaque, and hemodynamic characteristics of non-obstructive coronary lesions in the prediction of risk for acute coronary syndrome 期刊论文

编号：

cb3c3463-8833-406a-86d2-9b224cfb901b
作者：

Park, Jiesuck#^[1,2]Lee, Joo Myung#^[3,4]Koo, BonKwon*^[1,2,5]Choi, Gilwoo^[6];Hwang, Doyeon^[1,2];Rhee, TaeMin^[1,2];Yang, Seokhun^[1,2];Park, Jonghanne^[1,2];Zhang, Jinlong^[1,2];Kim, KyungJin^[1,2];Tong, Yaliang(童亚良)^[7]Doh, JoonHyung^[8];Nam, ChangWook^[9];Shin, EunSeok^[10];Cho, YoungSeok^[11];Chun, Eun Ju^[12];Choi, JinHo^[3,4];Norgaard, Bjarne L.^[13];Christiansen, Evald H.^[13];Niemen, Koen^[14,15];Otake, Hiromasa^[16];Penicka, Martin^[17];de Bruyne, Bernard^[17];Kubo, Takashi^[18];Akasaka, Takashi^[18];Narula, Jagat^[19];Douglas, Pamela S.^[20];Taylor, Charles A.^[6,21];
语种：

英文
期刊：

EUROPEAN RADIOLOGY ISSN：0938-7994 2019 年 29 卷 11 期 (6119 - 6128) ; NOV
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关键词：

Plaque atherosclerotic Acute coronary syndrome Coronary stenosis Hemodynamics Computed tomography angiography
摘要：

Objectives We explored the anatomical, plaque, and hemodynamic characteristics of high-risk non-obstructive coronary lesions that caused acute coronary syndrome (ACS). Methods From the EMERALD study which included ACS patients with available coronary CT angiography (CCTA) before the ACS, non-obstructive lesions (percent diameter stenosis < 50%) were selected. CCTA images were analyzed for lesion characteristics by independent CCTA and computational fluid dynamics core laboratories. The relative importance of each characteristic was assessed by information gain. Results Of the 132 lesions, 24 were the culprit for ACS. The culprit lesions showed a larger change in FFRCT across the lesion (Delta FFRCT) than non-culprit lesions (0.08 +/- 0.07 vs 0.05 +/- 0.05, p = 0.012). Delta FFRCT showed the highest information gain (0.051, 95% confidence interval [CI] 0.050-0.052), followed by low-attenuation plaque (0.028, 95% CI 0.027-0.029) and plaque volume (0.023, 95% CI 0.022-0.024). Lesions with higher Delta FFRCT or low-attenuation plaque showed an increased risk of ACS (hazard ratio [HR] 3.25, 95% CI 1.31-8.04, p = 0.010 for Delta FFRCT; HR 2.60, 95% CI 1.36-4.95, p = 0.004 for low-attenuation plaque). The prediction model including Delta FFRCT, low-attenuation plaque and plaque volume showed the highest ability in ACS prediction (AUC 0.725, 95% CI 0.724-0.727). Conclusion Non-obstructive lesions with higher Delta FFRCT or low-attenuation plaque showed a higher risk of ACS. The integration of anatomical, plaque, and hemodynamic characteristics can improve the noninvasive prediction of ACS risk in non-obstructive lesions.
推荐引用方式
GB/T 7714：

Park Jiesuck,Lee Joo Myung,Koo Bon-Kwon, et al. Relevance of anatomical, plaque, and hemodynamic characteristics of non-obstructive coronary lesions in the prediction of risk for acute coronary syndrome [J].EUROPEAN RADIOLOGY,2019,29(11):6119-6128.
APA：

Park Jiesuck,Lee Joo Myung,Koo Bon-Kwon,Choi Gilwoo,&Taylor Charles A..(2019).Relevance of anatomical, plaque, and hemodynamic characteristics of non-obstructive coronary lesions in the prediction of risk for acute coronary syndrome .EUROPEAN RADIOLOGY,29(11):6119-6128.
MLA：

Park Jiesuck, et al. "Relevance of anatomical, plaque, and hemodynamic characteristics of non-obstructive coronary lesions in the prediction of risk for acute coronary syndrome" .EUROPEAN RADIOLOGY 29,11(2019):6119-6128.
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