Considerable recent attention has been paid to homogeneous fluorescent DNA detection with the use of nanostructures as a universal "quencher", but it still remains a great challenge to develop such nanosensor with the benefits of low cost, high speed, sensitivity, and selectivity. In this work, we report the use of iron-based metal-organic framework nanorods as a high-efficient sensing platform for fluorescent DNA detection. It only takes about 4 min to complete the whole "mix-and-detect" process with a low detection limit of 10 pM and a strong discrimination of single point mutation. Control experiments reveal the remarkable sensing behavior is a consequence of the synergies of the metal center and organic linker. This work elucidates how composition control of nanostructures can significantly impact their sensing properties, enabling new opportunities for the rational design of functional materials for analytical applications. (C) 2015 Elsevier B.V. All rights reserved.
[1]Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China.
[2]Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
[3]Chongqing Normal Univ, Coll Phys & Informat Technol, Opt Engn Key Lab Chongqing Municipal Educ Commiss, Chongqing 40047, Peoples R China.
[4]King Abdulaziz Univ, Dept Chem, Jeddah 21589, Saudi Arabia.
[5]King Abdulaziz Univ, Ctr Excellence Adv Mat Res, Jeddah 21589, Saudi Arabia.
[6]Jilin Univ, China Japan Union Hosp, Dept Cardiol, Changchun 130033, Peoples R China.
(8.0+极速模式)