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Overexpression of Aldo-keto reductase family 1 B10 protein in ductal carcinoma in situ of the breast correlates with HER2 positivity 期刊论文

编号：

d71049e9-5f22-45a2-821a-699123b80656
作者：

Li, Zezhong[0]^[1];He, Xin[1]^[2];Xing, Shenyang[2]^[3];Ni, Jinsong[3]^[2];Zhang, Weihong[4]^[4];Xu, Xiaofang[5]^[5];Gao, Feng[6](高凤)^[6]Gai, Jinhong[7]^[5];Zhao, Zhihui[8]^[7];Li, Jianhua[9]^[8];Gong, Pengtao[10]^[9];Zhang, Guocai[11]^[8];Zhang, Xichen[12]^[9];
地址：

[1]Jilin University, Jilin Provincial Key Laboratory of Animal Embryo Engineering,Changchun,China
[2]Jilin University, Department of Pathology,Changchun,China
[3]Jilin University, Department of Animal Science,Changchun,China
[4]Jilin University, China-Japan Union Hospital,Changchun,China
[5]Jilin University, College of Animal Science and Veterinary Medicine,Changchun,China
[6]Ocean University of China, Institute of Evolution and Marine Biodiversity,Qingdao,China
[7]Fuwai Hospital, Center for Pulmonary Vascular Diseases,Beijing,China
[8]Jilin University, College of Veterinary Medicine,Changchun,China
[9]Jilin University, Key Laboratory of Zoonosis,Changchun,China
语种：

英文
期刊：

Cancer Biomarkers ISSN：1574-0153 2013 年 13 卷 3 期 (181 - 192)
收录：
关键词：

AKR1B10 correlation DCIS HER2
摘要：

BACKGROUND: Ductal carcinoma in situ of the breast constitutes the early stage of breast cancer when cancer cells are confined by the intact myoepithelial cell layer. Transition from DCIS to invasive carcinoma is a process yet poorly understood. MATERIALS AND METHODS: By liquid chromatography (LC) and mass spectrometry (MS/MS) methods, we analyzed this early event using paired samples of micro-dissected cells overlaid with focally disrupted myoepithelial layers and their adjacent counterparts within the intact duct from formalin-fixed paraffin-embedded blocks. RESULTS: AKR1B10, a member of Aldo-keto reductase family, was shown to be abundantly located in the filtering cells among a catalog of proteins. Moreover, strong correlation between AKR1B10 and HER2 positivity was found in an independent cohort of DCIS samples. CONCLUSION: AKR1B10 could become a potential diagnosis and therapeutic marker for early breast cancers with HER2 overexpression and poor prognosis. ? 2013 - IOS Press and the authors. All rights reserved.
推荐引用方式
GB/T 7714：

Li Zezhong/26663874300[0],He Xin/55589697800[1],Xing Shenyang/8709715300[2], et al. Overexpression of Aldo-keto reductase family 1 B10 protein in ductal carcinoma in situ of the breast correlates with HER2 positivity [J].Cancer Biomarkers,2013,13(3):181-192.
APA：

Li Zezhong/26663874300[0],He Xin/55589697800[1],Xing Shenyang/8709715300[2],Ni Jinsong/9250908400[3],&Zhang Xichen/57192513621[12].(2013).Overexpression of Aldo-keto reductase family 1 B10 protein in ductal carcinoma in situ of the breast correlates with HER2 positivity .Cancer Biomarkers,13(3):181-192.
MLA：

Li Zezhong/26663874300[0], et al. "Overexpression of Aldo-keto reductase family 1 B10 protein in ductal carcinoma in situ of the breast correlates with HER2 positivity" .Cancer Biomarkers 13,3(2013):181-192.

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