Objectives: To analyse the safety and efficacy of venous propofol sedation with close-loop administration system based on bispectral index (BIS) in elderly patients during endoscopic retrograde electroencephalography (ERCP). Methods: Selected 150 consecutive elderly patients undergoing EPCP procedures, anesthesia by propofol sedation of close-loop administration system with BIS target at 60. Patients were divided into 3 groups according to their age: group A, 50-70 years old (n=50); group B, aged 71-80 (n=50); group C, older than 80 years (n=50). Propofol dosage and adverse events (hypotension and hypoxaemia) during ERCP were the prime data to be recorded. Results: Lower target concentration of propofol might be more suitable for older patients. Median target concentration are respectively 2.6 mu g/mL, 2.1 mu g/mL and 1.6 mu g/mL for the three groups. Hypo-tension is more commonly happened in the younger group, and the incidence of hypoxaemia is significantly higher in the older groups, although the amount of adverse events was small. Low preoperative systolic blood pressure (<80 mm Hg) was more possible turned into perioperative hypo-tension, patients with abnormal pulmonary function was associated with hypoxaemia in groups B and C. Conclusions: Close-loop administration system is stable and dependable for intravenous anesthesia for ERCP. Lower dosage of propofol is suitable for elderly patients with the same target BIS of 60 More attention of hypoxaemia should be paid to the elderly patients, particularly with abnormal pulmonary function.
[1]Jilin Univ, China Japan Union Hosp, Anesthesiol Dept, 126th Xian Tai Ave, Changchun 130021, Jilin, Peoples R China.
[2]Jilin Univ, China Japan Union Hosp, Endoscop Ctr, 126th Xian Tai Ave, Changchun 130021, Jilin, Peoples R China.
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