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Protective effects of combined micronutrients on islet beta-cells of streptozotocin-induced diabetic mice 期刊论文

编号：

e061a92f-dfe6-48c8-864d-57d935744297
作者：

Chang, Ying#^[1,5]Zhang, GuiZhen(张桂珍)*^[1]Piao, SongLan^[1,3]Gao, Shen^[1];Zheng, DeMing(郑德明)^[1]Song, Yang^[2];Tsicopoulos, Anne^[5];Ying, Sun(孙英)^[4]
语种：

英文
期刊：

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH ISSN：0300-9831 2009 年 79 卷 2 期 (104 - 116) ; MAR
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摘要：

There is a tendency for the incidence of diabetes in a population to increase with an improvement in living standards. This would imply the involvement of nutritional factors in the development of diabetes, and so nutritional considerations could be a key aspect in the research and development of an effective remedy for diabetes. In this study, combined micronutrients (selenium, vitamin E, vanadium, and chromium) were orally supplemented to streptozotocin-induced diabetic mice. Results showed that combined micronutrients could decrease the high blood glucose levels (p<0.05 or p<0.01) of diabetic mice. The protective effects of combined micronutrients on structures of beta-cells in pancreatic islets of diabetic mice were observed histopathologically and ultrastructurally. In addition, the supplementation of combined micronutrients increased insulin expression by P-cells in pancreatic islets of diabetic mice at both translational and transcriptional levels. The immune molecular mechanisms involved were preliminarily regarded as downregulation of the expression of pathogenic T-helper 1 lymphocyte (Th1) cytokine tumor necrosis factor-alpha (TNF-alpha) (p<0.01.) along with upregulation of the expression of protective T-helper 2 lymphocyte Th2 cytokine interleukin 10 (IL-10) (p<0.01) which ameliorates the Th1/Th2 imbalance in diabetes. In conclusion, supplementation of combined micronutrients to diabetic mice could effectively improve disordered glucose metabolism, protect islet structures, and improve the function of beta-cells in pancreatic islets, which are affected by differential regulation of the expression of Th1/Th2 cytokines involved in the pathogenesis of diabetes.
推荐引用方式
GB/T 7714：

Chang Ying,Zhang Gui-Zhen,Piao Song-Lan, et al. Protective effects of combined micronutrients on islet beta-cells of streptozotocin-induced diabetic mice [J].INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH,2009,79(2):104-116.
APA：

Chang Ying,Zhang Gui-Zhen,Piao Song-Lan,Gao Shen,&Ying Sun.(2009).Protective effects of combined micronutrients on islet beta-cells of streptozotocin-induced diabetic mice .INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH,79(2):104-116.
MLA：

Chang Ying, et al. "Protective effects of combined micronutrients on islet beta-cells of streptozotocin-induced diabetic mice" .INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH 79,2(2009):104-116.
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