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Elevated sL1-CAM levels in BALF and serum of IPF patients 期刊论文

编号：

e4e28e1a-d299-4e92-8eea-d85fd989e3ee
作者：

Zhang, Yingwei(张英为)#^[1]Bi, Lintao(毕林涛)#^[3]Qiu, Yuying^[1];Wang, Yang^[2];Ding, Jingjing^[1];Zhuang, Yi^[1];Tian, Yaqiong^[1];Cai, Hourong(蔡后荣)*^[1]
语种：

英文
期刊：

RESPIROLOGY ISSN：1323-7799 2016 年 21 卷 1 期 (143 - 148) ; JAN
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关键词：

idiopathic pulmonary fibrosis L1 cell adhesion molecule lung cancer
摘要：

Background and objectiveIPF is a form of interstitial pneumonia of unknown origin that has a poor prognosis for which current treatments are limited. Recent studies have shown that EMT plays a role in IPF and tumour metastasis. L1-CAM has also been linked to EMT during tumour development and tumour metastasis. Our aim was to determine prospectively the level of L1-CAM in IPF patients.
MethodsForty consecutive Chinese patients (with IPF, 16; LC, 12; and CC, 12), but no apparent lung or other organ"s diseases were enrolled. Soluble L1-CAM (sL1-CAM), TGF-1, PDGF, -INF levels in BALF and serum sL1-CAM were measured using ELISA.
ResultsBALF sL1-CAM levels of IPF, LC and CC patients were 10.870.88ng/mL, 6.340.67ng/mL and 5.43 +/- 0.65ng/mL, respectively. BALF sL1-CAM concentration of IPF patients was significantly higher than that in LC and in CC patients. Besides, serum sL1-CAM levels in patients with IPF, LC and CC were 9.60 +/- 1.41ng/mL, 9.82 +/- 0.72ng/mL and 5.41 +/- 1.07ng/mL, respectively. The serum sL1-CAM levels in patients with IPF and LC were significantly higher than those in patients with CC (P<0.001, respectively).
ConclusionsThe concentrations of sL1-CAM both in BALF and in serum of patients with IPF are markedly increased compared with controls. This indicates that L1-CAM might be involved in the pathogenesis of IPF as well as that of LC.
The aim of this study was to analyse prospectively the level of sL1-CAM in IPF patients. The concentrations of sL1-CAM in IPF patients are markedly increased compared with controls. This indicates that L1-CAM might be involved in the pathogenesis of IPF as well as in LC.
推荐引用方式
GB/T 7714：

Zhang Yingwei,Bi Lintao,Qiu Yuying, et al. Elevated sL1-CAM levels in BALF and serum of IPF patients [J].RESPIROLOGY,2016,21(1):143-148.
APA：

Zhang Yingwei,Bi Lintao,Qiu Yuying,Wang Yang,&Cai Hourong.(2016).Elevated sL1-CAM levels in BALF and serum of IPF patients .RESPIROLOGY,21(1):143-148.
MLA：

Zhang Yingwei, et al. "Elevated sL1-CAM levels in BALF and serum of IPF patients" .RESPIROLOGY 21,1(2016):143-148.
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