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Comparison of Pathogenic Mechanisms Underlying Single and Recurrent Venous Thromboembolism Based on Gene Expression Profiling 期刊论文

编号：

e66d443b-483e-4185-9a71-0a884d84e5da
作者：

Xu, Dejun(徐德军)#^[1]Xu, Rutao(徐如涛)^[2]He, Liu(何柳)^[3]Xu, Tao^[4];Zhang, Zhenyu^[5];Han, Dongmei(韩冬梅)^[1]Du, Jianshi(杜建时)*^[1]
语种：

英文
期刊：

ANNALS OF VASCULAR SURGERY ISSN：0890-5096 2016 年 36 卷 (252 - 259) ; OCT
收录：
摘要：

Background: Unprovoked venous thromboembolism (VTE), generally divided into single and recurrent categories, is a common leading cause of morbidity and mortality in a real-world population. This study was aimed to explore the similarities and differences in the mechanisms of single and recurrent VTE.
Methods: Gene expression data (GSE19151) generated from 63 healthy controls, 32 single, and 38 recurrent VTE patients were analyzed. Differentially expressed genes (DEGs) were screened by Affy package and Kyoto Encyclopedia of Genes and Genomes and Gene Ontology enrichment analysis were performed using database for annotation, visualization, and integrated discovery. Based on the Search Tool for the Retrieval of Interacting Genes/Proteins database, protein-protein interaction network was visualized by Cytoscape, and modules were identified by CFinder. Finally, transcription factor regulatory networks were constructed.
Results: Totally, 559 and 294 DEGs were obtained from recurrent and single VTE, respectively. There were 202 upregulated and 58 downregulated genes overlapped between them. Terms of regulation of actin cytoskeleton enriched by downregulated genes and oxidative phosphorylation enriched by upregulated genes were found in 2 types of VTE. Leukocyte transendothelial migration and Jak-STAT signaling pathway were found related with recurrent VTE. In addition, genes including signal transducer and activator of transcription 3 (STAT3) involving in the Jak-STAT signaling pathway were highly connected nodes.
Conclusions: Actin cytoskeleton and oxidative phosphorylation may be involved in the common mechanisms of recurrent VTE and single VTE. Leukocyte migration and Jak-STAT signaling pathway and their related genes may be important for the development and recurrence of VTE.
推荐引用方式
GB/T 7714：

Xu Dejun,Xu Rutao,He Liu, et al. Comparison of Pathogenic Mechanisms Underlying Single and Recurrent Venous Thromboembolism Based on Gene Expression Profiling [J].ANNALS OF VASCULAR SURGERY,2016,36:252-259.
APA：

Xu Dejun,Xu Rutao,He Liu,Xu Tao,&Du Jianshi.(2016).Comparison of Pathogenic Mechanisms Underlying Single and Recurrent Venous Thromboembolism Based on Gene Expression Profiling .ANNALS OF VASCULAR SURGERY,36:252-259.
MLA：

Xu Dejun, et al. "Comparison of Pathogenic Mechanisms Underlying Single and Recurrent Venous Thromboembolism Based on Gene Expression Profiling" .ANNALS OF VASCULAR SURGERY 36(2016):252-259.
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