Intrinsic brain activity in a resting state incorporates components of the task negative network called default mode network (DMN) and task-positive networks called attentional networks. In the present study, the reciprocal neuronal networks in the elder group were compared with the young group to investigate the differences of the intrinsic brain activity using a method of temporal correlation analysis based on seed regions of posterior cingulate cortex (PCC) and ventromedial prefrontal cortex (vmPFC). We found significant decreased positive correlations and negative correlations with the seeds of PCC and vmPFC in the old group. The decreased coactivations in the DMN network components and their negative networks in the old group may reflect age-related alterations in various brain functions such as attention, motor control and inhibition modulation in cognitive processing. These alterations in the resting state anti-correlative networks could provide neuronal substrates for the aging brain. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
[1]Jilin Univ, Sino Japanese Friendship Hosp, Dept Radiol, Changchun 130033, Peoples R China.
[2]Yangzhou Univ, Clin Coll, Dept Radiol, Yangzhou 225001, Peoples R China.
[3]Peoples Hosp Hebei Prov, Dept Clin Pharmacol, Shijiazhuang 050051, Peoples R China.
[4]Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
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