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Efficient Synthesis of Beraprost Sodium 期刊论文

编号：

ed911f2e-bef7-4df4-9017-7a269fdc19d1
作者：

Wang Yue(王跃)#^[1]Hou Dalong^[2];Lu Haoze^[2];Zhang Baozhen^[2];Wang Ensi*^[2]
语种：

英文
期刊：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES ISSN：1005-9040 2016 年 32 卷 4 期 (581 - 585) ; AUG
收录：
关键词：

Beraprost sodium One-pot reaction Prins reaction Horner-Wadsworth-Emmons reaction
摘要：

An efficient and straightforward synthesis of beraprost sodium was developed with dicyclopentadiene as a starting material, a one-pot reaction product 5 as key intermediate and the Prins reaction and the Homer-Wadsworth-Emmons reaction as key steps. The structures of the key intermediate and the target compound were confirmed by H-1 NMR, C-13 NMR and MS. The purity of beraprost sodium identified by high performance liquid chromatography(HPLC) was identical to that of Japanese Pharmacopoeia(16th). This development will be used for the industrial synthesis of beraprost sodium.
推荐引用方式
GB/T 7714：

Wang Yue,Hou Dalong,Lu Haoze, et al. Efficient Synthesis of Beraprost Sodium [J].CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2016,32(4):581-585.
APA：

Wang Yue,Hou Dalong,Lu Haoze,Zhang Baozhen,&Wang Ensi.(2016).Efficient Synthesis of Beraprost Sodium .CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,32(4):581-585.
MLA：

Wang Yue, et al. "Efficient Synthesis of Beraprost Sodium" .CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 32,4(2016):581-585.
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