In order to examine the prognostic significance of miR-33a in patients with hepatocellular carcinoma (HCC), total RNA was extracted from 149 HCC biopsies, 36 of which were paired with para-carcinoma tissues, and miR-33a expression was measured by reverse transcription-quantitative polymerase chain reaction. The results demonstrated that miR-33a expression was decreased in HCC biopsies compared with normal liver tissue samples. It was also demonstrated that miR-33a expression was significantly associated with tumor foci number. Furthermore, overall and progression-free survival time was decreased in patients expressing low miR-33a with multiple tumor foci. Taken together, the low expression of miR-33a may be a potential risk factor for HCC.
[1]Tongji Univ, Sch Med, Dept Nucl Med, Shanghai Peoples Hosp 10, Middle 301 Yanchang Rd, Shanghai 200072, Peoples R China.
[2]Tongji Univ, Sch Med, Dept Pathol, Shanghai Peoples Hosp 10, Shanghai 200072, Peoples R China.
[3]Jilin Univ, China Japan Union Hosp, Tissue Bank, Changchun 130033, Jilin, Peoples R China.
[4]Jiangxi Prov Tumor Hosp, Dept Radiol, Nanchang 330029, Jiangxi, Peoples R China.
[5]Nanchang Third Hosp, Dept Breast Canc, Nanchang 330002, Jiangxi, Peoples R China.
[6]East China Normal Univ, Coll Chem & Mol Engn, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China.
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