[1]Department of Rhuematology, China-Japan Union Hospital, Jilin University, Changchun, China.
Objective: To determine the effects of disease activity and other risk factors on bone mineral density (BMD) in systemic lupus erythematosus (SLE). Methods: Lumbar and hip BMD were determined by dual energy X-ray absorptiometry (DXA) in 106 healthy controls and 223 premenopausal SLE females from Department of Rheumatology & Immunology, Third Hospital of Medical College of Jilin University during the period of 2010-2016. The SLE patients were divided into 2 groups, i.e. untreated and treated with glucocorticoid and immunosuppressives. Simple and multiple linear regression analyses were performed to determine the associations between BMD and disease-related variables.To completely eliminate the influences of glucocorticoid treatment on the results, the untreated SLE patients were chosen to investigate the risk factors with regression analysis. Results: In femoral neck and total hip, both the treated and untreated SLE patients had significantly lower BMD than the healthy controls (P < 0.01).In greater trochanter, the treated SLE group had significantly lower BMD than the untreated group (P < 0.05). Regression analysis showed that long disease duration high (SLE disease activity index) SLEDAI and anti-dsDNA antibodies increasing were the risk factors of low BMD (P < 0.05), especially high SLEDAI. Conclusion: SLE itself may result in low BMD, especially in patients with high SLEDAI. Hip joints are predominatly affected. Long disease duration and anti-dsDNA antibodies increasing is also closely associated with low BMD in SLE.
(8.0+极速模式)