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Lidocaine, an anesthetic drug, protects Neuro2A cells against cadmium toxicity 期刊论文

编号：

f9b16148-f49d-4042-aca4-8ca471468f33
作者：

Chen, Peng(陈鹏)#^[1]Zhang, Wenyu(张闻宇)^[1]Li, Xuefeng(李学锋)^[1]Li, Longyun(李龙云)*^[1]
语种：

英文
期刊：

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH ISSN：1596-5996 2019 年 18 卷 5 期 (1033 - 1039) ; MAY
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关键词：

Lidocaine Anesthesia Neuroprotection Cadmium toxicity
摘要：

Purpose: To investigate the neuroprotective effect of lidocaine in Neuro2A cells
Methods: Differentiated N2a cells were used in this study. Cell viability and neuroprotection were assessed using dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and trypan blue assays, while Bax/Bcl-2 expression was assayed by western blotting. Mitochondrial membrane potential, reactive oxygen species and calcium levels were measured using flow cytometry.
Results: Lidocaine protected differentiated N2a cells against cadmium-induced toxicity, and also attenuated cadmium toxicity-induced changes in mitochondrial membrane potential (MMP), reactive oxygen species (ROS) and calcium (Ca2+) levels. Furthermore, Bax/Bcl-2 ratio, which was disrupted by cadmium, and cadmium-induced apoptosis, were reversed by lidocaine.
Conclusion: Lidocaine protects differentiated N2a cells against cadmium-induced toxicity by reversing apoptosis. Thus, lidocaine is a potential neuroprotective agent.
推荐引用方式
GB/T 7714：

Chen Peng,Zhang Wenyu,Li Xuefeng, et al. Lidocaine, an anesthetic drug, protects Neuro2A cells against cadmium toxicity [J].TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH,2019,18(5):1033-1039.
APA：

Chen Peng,Zhang Wenyu,Li Xuefeng,Li Longyun.(2019).Lidocaine, an anesthetic drug, protects Neuro2A cells against cadmium toxicity .TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH,18(5):1033-1039.
MLA：

Chen Peng, et al. "Lidocaine, an anesthetic drug, protects Neuro2A cells against cadmium toxicity" .TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH 18,5(2019):1033-1039.
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